Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass

Organ protection, volatile anesthetics, postconditioning.

Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane. Evaluation of organ function and inflammatory mediators in the blood.

Inclusion criteria:

• CABG and/or heart valve surgery with CPB
• Ejection fraction (EF) = 30%
• Canadian Cardiovascular Society (CCS) classification = 3
• Ages 18 to 90 years old

Exclusion criteria:

• Pulmonary disease: forced expiratory volume in one second (FEV1) < 80%; FEV1/forced vital capacity (FVC) < 70%
• Renal disease and/ or creatinine-clearance < 60 ml/min
• Previous cardiac surgery
• Emergency procedures
• Postoperative intra aortic balloon pump (IABP) requirement
• Myocardial infarction < 7d
• Steroid treatment
• Insulin-dependent diabetes
• Pregnancy