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The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known.
The objectives of the present study are:
Thyroid autoantibodies and / or abnormal thyroid function are associated with fertility problems.
A possible explanation for this is, an influence of thyroid autoantibodies on the functioning of the thyroid gland. It is therefore recommended to check thyroid gland function and for the presence of autoantibodies before pregnancy. In general, 2 types of thyroid autoantibodies are known: anti-thyreoperoxidase autoantibodies and anti-thyroglobulin autoantibodies.
In case of abnormal thyroid function, treatment is sometimes necessary in regards to fertility. The risk of abnormal thyroid function is increased in women with thyroid autoantibodies during pregnancy. Therefore, thyroid function is regularly monitored during pregnancy in women with thyroid antibodies. The influence of thyroid autoantibodies on thyroid function in pregnancy after fertility treatment is not well known.
The objectives of the present study are:
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Tg AB positive, TPO AB negative | Active Comparator | Includes patients with only anti-thyroglobuline autoantibodies present and no anti-thyreoperoxydase antibodies at start of fertility treatment. |
|
| Tg AB negative, TPO AB negative | Active Comparator | Includes patients without thyroid autoantibodies at start of fertility treatment |
|
| Tg AB positive, TPO AB positive | Active Comparator | Includes patients with anti-thyroglobuline autoantibodies and anti-thyreoperoxydase antibodies at start of fertility treatment. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood test | Diagnostic Test | blood test for thyroid antibodies and thyroid function (TSH, FT4) |
|
| Measure | Description | Time Frame |
|---|---|---|
| thyroid fonction | TSH, FT4 evolution during pregnancy | 12 months |
| cumulative delivery rate | live birth delivery after IVF stimulation | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| cumulative pregnancy rate | pregnancy rate after IVF stimulation | 12 months |
| miscarriage rate | miscarriage rate after IVF stimulation |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| valerie uvin, md | Contact | 486073292 | 0032 | valerieuvin@hotmail.com |
| david unuane, md phd | Contact | 024774671 | 0032 | david.unuane@uzbrussel.be |
| Name | Affiliation | Role |
|---|---|---|
| valerie uvin, md | UZ Brussels | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| UZ Brussel | Recruiting | Brussels | 1090 | Belgium |
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| follow up treatment outcome | Other | questionnaire for treatment outcome: pregnancy, no pregnancy, miscarriage, delivery |
|
| 12 months |
| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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