The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes

The Effect of Thyroid Antibodies on Female Reproductive Function and Pregnancy Outcomes

Some women at reproductive age have positive antithyroid antibodies (ATAs). Thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) are the most common ATAs. This study aimed to evaluate the impact of ATAs on maturation of women reproductive system and pregnancy outcomes.

Inclusion Criteria:

• Age during 18-45y;
• Women tested for TPOAb and/or TgAb, TSH, free T3, free T4, total T3 and total T4 during the 1st trimester of pregnancy

Exclusion Criteria:

• Multiple pregnancies;
• Age < 18 y or > 40 y;
• L-T4 or PTU intervention before pregnancy;
• Other autoimmune diseases.