Prevalence of Thyroid Dysfunction and Anti-thyroid Antibodies in Infertile Women

Prevalence of Thyroid Dysfunction and Anti-thyroid Antibodies in Infertile Women

The study population will be divided into three groups:

• Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,

• Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and

• Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.

  . All women will be subjected to:

• Informed consent

• Full history taking, including age, duration of infertility and whether primary or secondary

• General and pelvix examination

• Trans-vaginal ultrasonography

• Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)

• Determination of ovulatory status

• Determination of of tubal patency

• Determination of presence of male factor

• Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

The study population will be divided into three groups:

• Group (A) consisting of 40 infertile women with either unexplained or anovulatory infertility with/without associated male factor of infertility,

• Group (B) consisting of 40 infertile women with tubal (mechanical) factor of infertility with/without associated male factor of infertility, and

• Group (C) consisting of 40 women with exclusive male factor of infertility and will be used as a control group.

  . All women will be subjected to:

• Informed consent

• Full history taking, including age, duration of infertility and whether primary or secondary

• General and pelvix examination

• Trans-vaginal ultrasonography

• Determination of hormonal profile (FSH, LH, Estradiol, Prolactin)

• Determination of ovulatory status (by previous documented history of induction of ovulation OR previous ultrasonography OR previous estimation midluteal serum progesterone, etc …)

• Determination of of tubal patency (by previous hysterosalpingiography or laparoscopy)

• Determination of presence of male factor (by seminal fluid analysis)

• Determination of TSH and antithyroid antibodies (antithyroglobulin and antithyroid peroxidase) blood levels

Inclusion Criteria:

• - Age: 18 - 38 years
• Infertile women whether due to functional, anatomical, male factors OR unexplained OR combined factors

Exclusion Criteria:

• - Age: below 18 and above 38 years
• Patients with autoimmune diseases (such as lupus and rheumatoid arthritis)
• Acute illness that require hospitalization
• Patients on the following medications: steroids, dopamine, iodine, amiodarone, lithium, donperidone, thyroid hormone, and phenytoin.
• Patients who work at night.