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The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis.
The purpose of this research study is to investigate the effectiveness of a memory enhancement technique in persons with Multiple Sclerosis (MS). The study is designed to research how well this technique can help people with MS improve their memory and their ability to function better in everyday life.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Experimental | Experimental | The experimental group will receive memory enhancement exercises administered twice a week for 4 weeks (8 training sessions). |
|
| Control group | Placebo Comparator | The control group will receive placebo memory enhancement exercises administered twice a week for 4 weeks (8 training sessions). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Strategy-Based Training to Enhance Memory (STEM) | Behavioral | Protocol designed to improve memory functioning in individuals with neurological injuries administered for 4 weeks (8 training sessions). |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in scores on self-report measure of everyday cognition (subjective) | Perceived Deficits Questionnaire | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in scores on self-report measure of everyday cognition (objective) | Ecologic Memory Simulations | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in auditory processing speed | Paced Auditory Serial Edition Test | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in information processing speed |
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Inclusion Criteria:
Exclusion Criteria:
For Optional MRI:
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| Name | Affiliation | Role |
|---|---|---|
| Nancy D Chiaravalloti, PhD | Kessler Foundation | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kessler Foundation | East Hanover | New Jersey | 07936 | United States | ||
| Kessler Rehabilitation Center |
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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Participants will be blind as to which treatment group they are being placed. Study staff conducting baseline and follow-up assessments will also be blind as to which group participants are placed. Study staff conducting intervention sessions will be blind to participants' baseline and follow-up assessment performance.
| Placebo control exercises | Behavioral | Placebo control memory exercises will be administered for 4 weeks (8 training sessions). |
|
Symbol Digit Modalities Test
| Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in episodic verbal memory and learning | California Verbal Learning Test - 2nd Edition | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in visuospatial memory | Brief Visuospatial Memory Test - Revised | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in ability in spontaneous production of words | Controlled Oral Word Association Test | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in visual perception | Benton Judgment of Line Orientation | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Changes in executive function | Delis-Kaplan Executive Function System - Sorting | Baseline (week 1), immediately post-intervention (week 6) and long-term follow-up (week 6 months post-intervention) |
| Marlton |
| New Jersey |
| 08053 |
| United States |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |