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Impairments in higher level cognitive processing, such as new learning and memory, are common in Multiple Sclerosis (MS) and negatively impact multiple aspects of everyday life, including occupational and social functioning. Despite this, few studies have attempted to remediate these cognitive deficits in order to improve everyday functioning. While not applied in traditional rehabilitation protocols as of yet, many techniques from cognitive psychology significantly improve learning and memory in healthy persons. These techniques include the generation effect (GE), the spacing effect (SE), and the testing effect (TE). These techniques have recently been incorporated into an 8-session treatment protocol, Stylistic Memory Enhancement (SME), designed to teach participants about each of the techniques, train them on how to apply the techniques in daily life and practice their application to daily life memory demanding situations. The protocol includes teaching participants how to restructure a memory demanding situation in order to make optimal use of self-generation, spaced learning and self-testing. The objective of the study is to test the efficacy of the SME in an MS population.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Experimental | The experimental group will meet with a study team member twice a week for 4 weeks (8 sessions) and receive memory strategy training. |
|
| Control | Placebo Comparator | The control group participants will meet with a study team member twice a week for 4 weeks (8 sessions) and receive control memory exercises. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Stylistic Memory Enhancement | Behavioral |
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| Measure | Description | Time Frame |
|---|---|---|
| California Verbal Learning Test (CVLT-II- Total learning | Measure of change in new learning | Baseline and post-intervention (5 weeks between testing sessions) |
| Measure | Description | Time Frame |
|---|---|---|
| Memory Functioning Questionnaire | Measure of change in Self-report of everyday memory functioning | Baseline and post-intervention ( 5 weeks between testing sessions) |
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Inclusion Criteria:
Clinically definite MS between the ages of 18 and 59. Participants must have impairment in new learning (determined by an in-person screen) with intact language comprehension.
Exclusion Criteria:
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| ID | Term |
|---|---|
| D009103 | Multiple Sclerosis |
| ID | Term |
|---|---|
| D020278 | Demyelinating Autoimmune Diseases, CNS |
| D020274 | Autoimmune Diseases of the Nervous System |
| D009422 | Nervous System Diseases |
| D003711 | Demyelinating Diseases |
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Double blind placebo controlled randomized control trial
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| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |