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| ID | Type | Description | Link |
|---|---|---|---|
| UL1TR002649 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Center for Advancing Translational Sciences (NCATS) | NIH |
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This study is about how brain function and structure is different between two universities. Participant in this project will contribute to a better understanding of how universities affect the brain.
Some study details are purposely omitted at this time to preserve scientific integrity. Now that the study is completed, full details are included below.
The true purpose of this study was to investigate the psychometric properties of the two computer tasks that participants completed. Specifically, researchers wanted to know if they would be able to accurately measure motivated empathy. To better understand this, participants were asked to rate images of people expressing pain and were told that these were either students from their university or students from a different university. This was not the case. The faces shown were random images produced for a research study.
Researchers also wanted to know if they could accurately measure moral decision making and how those judgments relate to aggression. To examine this, participants were asked whether various scenarios were immoral and then asked about aggressive tendencies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Low psychopathy distribution | Other | Participants who score at the low end of the psychopathy distribution |
|
| High psychopathy distribution | Other | Participants who score at the high end of the psychopathy distribution |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Psychological task | Behavioral | Participants will complete a psychological task that evokes antisocially- and prosocially-motivated empathic responding |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in Prefrontal Cortex Brain Activity Assessed by fMRI | Blood-Oxygen-Level-Dependent signal change in the cognitive empathy brain network will be assessed using functional MRI | Baseline to 3 hours |
| Change in Accuracy of Empathic Pain Judgments | Difference in pain judgment scores rated from 1 (low) to 4 (high) between antisocial vs prosocial empathy trials | Baseline to 3 hours |
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Inclusion Criteria:
Exclusion Criteria:
• Not meeting the inclusion criteria listed above.
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| Name | Affiliation | Role |
|---|---|---|
| David Chester, PhD | Virginia Commonwealth University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Virginia Commonwealth University | Richmond | Virginia | 23298 | United States |
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| ID | Title | Description |
|---|---|---|
| FG000 | Low Psychopathy Distribution | Participants who score at the low end of the psychopathy distribution |
| FG001 | High Psychopathy Distribution | Participants who score at the high end of the psychopathy distribution |
| Title | Milestones | Reasons Not Completed | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Overall Study |
|
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| ID | Title | Description |
|---|---|---|
| BG000 | Low Psychopathy Distribution | Participants who score at the low end of the psychopathy distribution |
| BG001 | High Psychopathy Distribution | Participants who score at the high end of the psychopathy distribution |
| Units | Counts |
|---|---|
| Participants |
|
| Title | Description | Population Description | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Denominator Units Selected | Denominators | Classes |
|---|---|---|---|---|---|---|---|---|---|
| Age, Continuous | Mean |
| Type | Title | Description | Population Description | Reporting Status | Anticipated Posting Date | Parameter Type | Dispersion Type | Unit of Measure | Calculate Percentage | Time Frame | Units Analyzed | Denominator Units Selected | Arm/Group Information | Denominators | Classes | Analyses | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Primary | Change in Prefrontal Cortex Brain Activity Assessed by fMRI | Blood-Oxygen-Level-Dependent signal change in the cognitive empathy brain network will be assessed using functional MRI | Posted | Mean | Standard Deviation | Percent BOLD Signal Change | Baseline to 3 hours |
|
3 hours
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| ID | Title | Description | Deaths (Affected) | Deaths (At Risk) | Serious Events (Affected) | Serious Events (At Risk) | Other Events (Affected) | Other Events (At Risk) |
|---|---|---|---|---|---|---|---|---|
| EG000 | All Participants | Participants who score at the low or high end of the psychopathy distribution Because all participants received the same intervention, adverse events were not recorded separately by arm. |
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| Title | Organization | Phone | Extension | |
|---|---|---|---|---|
| David Chester | Virginia Commonwealth University | 8048287624 | dschester@vcu.edu |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP | Yes | Yes | No | Study Protocol and Statistical Analysis Plan | Sep 4, 2019 | Apr 6, 2022 | Prot_SAP_001.pdf |
| ICF | No | No | Yes | Informed Consent Form | Jun 5, 2019 | Sep 30, 2021 | ICF_000.pdf |
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| ID | Term |
|---|---|
| D012919 | Social Behavior |
| ID | Term |
|---|---|
| D001519 | Behavior |
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| BG002 | Total | Total of all reporting groups |
| years |
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| Sex: Female, Male | Count of Participants | Participants |
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| Race/Ethnicity, Customized | Count of Participants | Participants |
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| Region of Enrollment | Number | participants |
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| Units | Counts |
|---|
| Participants |
|
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| Primary | Change in Accuracy of Empathic Pain Judgments | Difference in pain judgment scores rated from 1 (low) to 4 (high) between antisocial vs prosocial empathy trials | Posted | Mean | Standard Deviation | difference in pain scores | Baseline to 3 hours |
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| 0 |
| 36 |
| 0 |
| 36 |
| 0 |
| 36 |
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