Not provided
| ID | Type | Description | Link |
|---|---|---|---|
| K99MH132873 | U.S. NIH Grant/Contract | View source |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Name | Class |
|---|---|
| National Institute of Mental Health (NIMH) | NIH |
Not provided
Not provided
Not provided
Learning to make good decisions in the present, and accurately recalling events and information from the past, are critical aspects of human cognition that are often impaired in many psychiatric disorders. This project aims to identify the how the choices individuals make influence what, and how, people remember by combining disparate techniques in computational modeling and direct brain recordings in human subjects. The researcher developed a dual-task paradigm, probing how decisions in one task affect immediate recognition memory. To examine the neural mechanisms underlying model-free RL's influence on memory, the researcher will record local field potential (LFP) and single neuron activity in various brain regions as epilepsy patients perform the proposed task. The results of this project will identify specific neurocomputational mechanisms unifying decision-making and memory processes.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Value-manipulation | Experimental | Participants with epilepsy will complete a behavioral task in which they use a laptop computer to do a decision-making and memory task. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Value-manipulation | Behavioral | During the decision-making task, different choices are assigned different values probabilistically. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Local-field potentials changes | Detection of local-field potentials (LFPs) in the various regions (hippocampus, amygdala, and frontal cortex). Local field potentials are the biological voltages recorded by macroelectrodes implanted in participant's subcortical regions as part of their treatment for epilepsy. LFP changes (measured as increases or decreases in voltage) as a function of participant behavior will be recorded, and in response to the task manipulation of the value of choices during the decision-making task | During task participation, approx. 30-45 min in the first 2 weeks of hospital stay |
| Firing rate changes | Single-neuron activity recorded from the hippocampus, amygdala, and frontal cortex. Single-neuron activity refers the micro-scale changes in single-neuron action potentials recorded by microelectrodes implanted in subcortical regions. Firing rate changes (measured as difference in spikes/seconds [Hz]) will be reported for neurons as a function of how behavior changes when the value of choices is altered. | During task participation, approx. 30-45 min in the first 2 weeks of hospital stay |
| Measure | Description | Time Frame |
|---|---|---|
| Reaction time | Reaction times involve measuring how quickly the participant makes each choice during the decision-making and memory tasks, in milliseconds. This will be recorded by logging keypresses and mouse inputs to the behavioral computers. Slow reaction times indicate increased cognitive processing. | During task participation, approx. 30-45 min in the first 2 weeks of hospital stay |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Salman E Qasim, PhD | Contact | 212-824-9531 | salman.qasim@mssm.edu |
| Name | Affiliation | Role |
|---|---|---|
| Salman E Qasim, PhD | Icahn School of Medicine at Mt. Sinai | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rutgers Robert Wood Johnson Medical School | Recruiting | New Brunswick | New Jersey | 08901 | United States |
Access to the raw, de-identified behavioral and neural data will be limited to qualified researchers due to the potential for misuse of participant demographic and neural data within 12 months following article publication. Datasets generated by this project will be made available through the National Institute of Mental Health Data Archive (NDA).
Within 12 months following article publication
The datasets will be hosted and available free of charge to approved researchers.
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| Number of hit rates for decision-making | Choices in decision-making task involved logging the decision-making selections that participants make. This will be recorded by logging keypresses and mouse inputs (left or right) to the behavioral computers. This will be used to track whether participants decisions change when value manipulations occur. | During task participation, approx. 30-45 min in the first 2 weeks of hospital stay |
| Number of hit rates for Memory performance | Memory performance involved logging the memory-recognition selections that participants make. This will be recorded by logging keypresses and mouse inputs (old or new) to the behavioral computers. This will be used to track whether participants memory performance changes when value manipulations occur. | During task participation, approx. 30-45 min in the first 2 weeks of hospital stay |