Human Neural Correlates of Multi-Timescale Inference

Neuronal Mechanisms of Human Cognition

Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.

The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.

Inclusion Criteria:

• Epilepsy patients undergoing intracranial electrode monitoring for uncontrolled seizures.
• no lesions identified in the participants' brains
• capable of giving consent

Exclusion Criteria:

• seizure activity during task recording
• electrodes in regions of interest are identified to be the seizure focus
• task performance outside of the normal range as determined from online studies with healthy participants