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| ID | Type | Description | Link |
|---|---|---|---|
| R00NS127855 | U.S. NIH Grant/Contract | View source |
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Adult epilepsy patients who are undergoing intracranial monitoring will participate in a simple behavioral task during the clinical recording period.
The investigators will analyze recorded neural activity, eye movements, and behavioral responses from epilepsy patients undergoing intracranial monitoring with clinically-relevant microelectrodes in hippocampus that perform a decision-making task. The participants will perform 1 session of the task during their monitoring period. Behavioral responses will be fit to inference models to identify strategies subjects use, and neural recordings (neuronal firing and low frequency activity) will be correlated with task features by comparing results to those produced by randomized (bootstrapped) data. Neural activity and corresponding behavioral strategies for each participant will be used to refine theoretical recurrent neural network models of hippocampal engagement in multi-timescale inference.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Flexible Decision Making Task |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Decision-making task | Behavioral | Patients will be asked to play a decision-making game in which they hear a tone and must identify its source. |
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| Measure | Description | Time Frame |
|---|---|---|
| Pupil size changes with respect to task features | pupil size will be measured with a portable eye-tracking device and correlated with task features | continuous recording during task, up to 30 minutes |
| Behavioral Responses | Patient selects one of two choices on each trial using the computer keyboard | Approximately 10 seconds per trial, up to 30 minutes total |
| Intracranial electrode recordings to measure changes in brain activity during decision making | Intracranial neural recordings from patients who are implanted with electrodes for clinical purposes tha take place during the decision-making task | duration of the task, approximately 30 minutes |
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Inclusion Criteria:
Exclusion Criteria:
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Epilepsy patients with intractable seizures who are undergoing clinical continuous intracranial recordings of the brain's electrical activity to assess the seizure focus location.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Tahra Eissa | Contact | (303) 492-6974 | tahra.eissa@cuanschutz.edu |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Colorado Anschutz | Aurora | Colorado | 80045 | United States |
Given that these are patients, the investigators cannot directly share their identifiable information without conflicting with HIPAA compliance
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| eye tracking | Behavioral | Patients will have simultaneous eye-tracking performed while playing the decision-making game |
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