Postprandial Effect of High-starch Meals in Individuals With Low and High Copy Number of the Salivary Amylase Gene

Postprandial Effect of High-starch Meals in Individuals With Low and High Copy Number of the Salivary Amylase Gene

Individuals with low copy numbers of salivary amylase gene have lower salivary amylase levels and might therefore have decreased capacity to metabolize starch into glucose. We will in a randomized crossover meal study examine the postprandial response of high-starch meals in individuals with either low or high copy number of the salivary amylase gene.

Inclusion Criteria:

• Participant in the Malmö Offspring Study
• Genotyped for AMY1 copy number variation and selected for having either low (2-4) or high (10 or above) copy number of AMY1
• Gender: both males and females
• Completed information on dietary habits

Exclusion Criteria:

• Allergic to wheat, gluten intolerant or on a low-carbohydrate diet
• Inability to eat up to 4 slices of white bread in 15 minutes
• Use of medication known to influence glucose metabolism, appetite or saliva flow
• Diagnosed diabetes or high fasting plasma glucose (above 6.1 mmol/L)
• Smoking