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The aim of this observative, prospective study with cross-sectional design is to explore possible correlations/associations between microcirculation parameters and sublingual endothelial glycocalyx in sepsis. Therefore, 30 critically ill septic patients and 10 healthy controls were enrolled.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Septic patients | ICU patients with resuscitated sepsis, based on the sepsis-3 criteria. (n=30) |
| |
| Healthy controls | Apparently healthy controls (n=10) |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Microcirculation and Glycocalyx assessment | Other | Non-invasive assessment of endothelial glycocalyx dimensions (PBR) and microcirculatory parameters (e.g. PPV, PVD, TVD, MFI) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Correlations between Perfused Boundary Region (PBR) and Microvascular Flow Index (MFI) measured sublingually | Glycocalyx thickness will be measured with PBR (in μm) and MFI will be assessed in points. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation). | During ICU stay, an average of 2 days after sepsis onset |
| Correlations between Perfused Boundary Region (PBR) and Proportion of Perfused Vessels (PPV) measured sublingually | Glycocalyx thickness will be measured with PBR (in μm) and PPV will be assessed in percentage. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation). | During ICU stay, an average of 2 days after sepsis onset |
| Correlations between Perfused Boundary Region (PBR) and Perfused Vessel Density (PVD) measured sublingually | Glycocalyx thickness will be measured with PBR (in μm) and PVD will be assessed in mm/mm^2. Possible correlations at a given timepoint will be explored (e.g. Spearman's Correlation). | During ICU stay, an average of 2 days after sepsis onset |
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Inclusion Criteria - septic ICU cohort:
Inclusion Criteria - healthy controls:
- Adult healthy individuals
Exclusion Criteria (for all groups):
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| Name | Affiliation | Role |
|---|---|---|
| Philipp Kümpers, MD | University Hospital Muenster | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitiy Hospital Muenster | Münster | 48149 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31340868 | Derived | Rovas A, Seidel LM, Vink H, Pohlkotter T, Pavenstadt H, Ertmer C, Hessler M, Kumpers P. Association of sublingual microcirculation parameters and endothelial glycocalyx dimensions in resuscitated sepsis. Crit Care. 2019 Jul 24;23(1):260. doi: 10.1186/s13054-019-2542-2. |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| ID | Term |
|---|---|
| D008833 | Microcirculation |
| ID | Term |
|---|---|
| D001775 | Blood Circulation |
| D002320 | Cardiovascular Physiological Phenomena |
| D002943 | Circulatory and Respiratory Physiological Phenomena |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |