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The aim of this observative, prospective study is to evaluate if and to what extent glycocalyx damage/microcirculation data at admission in the ICU as well as during ICU stay can be predictive of mortality and clinical course in patients presenting with the suspicion of sepsis/septic shock. Therefore, the enrollment of ca 100 ICU patients is planned.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients with suspected sepsis | Patients admitted in the ICU with the clinical suspicion of infection/sepsis. |
| |
| Non-sepsis Patients (control group) | Patients admitted in the ICU with other conditions apart from infection/sepsis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Endothelial Glycocalyx | Other | Non-invasive assessment of endothelial glycocalyx dimensions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Predictive value of glycocalyx thickness regarding clinical course. | Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). Clinical course will be estimated with the use of e.g. Sequential Organ Failure Assessment (SOFA) score (in points). | Hospital stay, an expected time of 4 weeks. |
| Predictive value of glycocalyx thickness regarding mortality. | Glycocalyx thickness measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in µm). | Hospital stay, an expected time of 4 weeks. |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation of glycocalyx thickness with disease severity. | Glycocalyx thickness will be measured with the use of GlycoCheck System (Perfused Boundary Region - PBR, in μm). Disease severity will be assessed with ICU scores (e.g. SOFA Score - pts) | Hospital stay, an expected time of 4 weeks. |
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Inclusion Criteria:
Exclusion Criteria:
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Non-consecutive patients admitted in the ICU of University Hospital Münster, Germany.
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| Name | Affiliation | Role |
|---|---|---|
| Philipp Kümpers, MD | University Hospital Muenster | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universitiy Hospital Muenster | Münster | 48149 | Germany |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| D013568 |
| Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |