Early Detection of Glycocalyx Damage in Emergency Room Patients

Early Detection of Glycocalyx Damage in Emergency Room Patients

Aim of the study is to evaluate to what extent a glycocalyx damage measured in the ER in patients presenting with sepsis correlates with their clinical course and if it can be used as a clinical stratification tool and mortality predictor.

The study will focus on the changes of the microcirculation and how they correlate with the macrocirculation, as well as microbiologic parameters. In the study will participate ca. 300 patients with sepsis, as well as 30 patients without sepsis and 30 healthy individuals.

Inclusion Criteria:

Patients with suspected sepsis

• Adult patients presenting to the ER with the clinical suspicion of infection
• Indication for hospital admission

Patients without sepsis

• Adult patients presenting to the ER with other conditions apart from sepsis/infection.

Healthy individuals

• Adult healthy individuals.

Exclusion Criteria (for all groups):

• Underage persons
• Pregnant women
• Oral mucosal injuries