Acute Bronchiolitis in Infants and Allergic Asthma

Risk of Allergic Asthma Occurring in the Long Term From an Episode of Acute Bronchiolitis in Infants: Clinical, Allergological and Functional Evaluation in the Long Term

Predicting the risk of allergenic sensitizations and asthma development in the first year of life is difficult.

Investigator decided to follow prospectively two cohorts of infants with acute bronchiolitis, hospitalized or treated at home, from the epidemic seasons of 2011-2012 and 2015-2017 to know their respiratory evolution, especially if they developed allergen sensitization and / or asthma.

Follow-up consultation 6 years after an episode of acute bronchiolitis at Clermont-Ferrand hospital with:

• Consultation with a pneumopediatrician: collection of respiratory symptoms, respiratory treatments, evaluation of the atopic site and environmental risk factors for bronchial aggression, especially passive smoking;
• Physical examination ;
• Evaluation of precariousness during the same interview with the EPICES questionnaire;
• Prick tests with positive control (histamine) and negative (physiological saline) and prick for the main pneumallergens (mites, alternaria, grasses, cat and dog) and trophallergens (egg, milk, fish, soy, wheat, peanut);
• Blood test with blood count, determination of specific IgE (5 pneumallergens and 5 trophallergens), dosage of sRAGE;
• Fonctionnal respiratory test with reversibility test

Inclusion Criteria:

- Acute bronchiolitis in an infant less than one year old, included in studies KL6 (winter period 2011-2012) or CC16 (winter period 2015-2016) at clermont-ferrand hospital.

Exclusion Criteria:

• Bronchopulmonary dysplasia;
• History of prematurity <34 AS;
• Mucoviscidosis;
• known immune deficiencies;
• Primary ciliary dyskinesia suspected;
• Congenital heart disease;
• Acute renal failure.
• Refusal of parents to participate