Aflibercept With and Without Micropulse Laser in Diabetic Macular Edema

Aflibercept With Adjuvant Micro-Pulsed Yellow Laser Versus Aflibercept Monotherapy in Treatment of Diabetic Macular Edema.

prospective study evaluating the impact of subthreshold micropulsed laser on the number of Aflibercept injections when used as an adjuvant therapy in eyes with diabetic macular edema.

Inclusion Criteria:

• older than 18 years old
• diagnosed with DME with central macular thickness (CMT) more than 250 µm measured by OCT
• best corrected visual acuity (BCVA) between 20/400 and 20/40.

Exclusion Criteria:

• patients with intra-ocular surgery as cataract surgery within 6 months
• prior intravitreal injection of any drug within the preceding 6 months
• panretinal photocoagulation (PRP) within the former 4 months.
• Patients with previous macular laser
• patients with vitreo-macular traction (VMT) syndrome
• severe glaucoma
• other retinal vascular diseases
• conditions that impede the OCT interpretation