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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment | Active Comparator | Treatment of cases of melasma using Q switched Nd YAG laser and Fractional CO2 laser separately and in combination |
|
| Follow -up period | No Intervention | follow up of the treated cases for 2 months |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Q switched Nd YAG laser | Device | Laser device emitting Q switched Nd YAG aiming for skin toning |
|
| Measure | Description | Time Frame |
|---|---|---|
| Modified Melasma Area and Severity index change. | Evaluate the efficacy of Q-switched 1,064nm Nd: YAG & fractional Co2 laser in the treatment of melasma by comparing the results through measuring modified MASI score before treatment and after treatment and follow-p period. | 6 months to 1 year |
| Melanin index change. | Evaluate the efficacy of Q-switched 1,064nm Nd: YAG & fractional Co2 laser in the treatment of melasma by comparing the results by taking spectrophotometer readings (melanin index) before treatment and after treatment and follow-p period. | 6 months to 1 year |
| percentage of clinical improvement | Evaluate the efficacy of Q-switched 1,064nm Nd: YAG & fractional Co2 laser in the treatment of melasma by comparing the results of masked dermatologists' observation of clinical photographs before treatment and after treatment and follow-p period. | 6 months to 1 year |
| patient satisfaction rate | Evaluate the efficacy of Q-switched 1,064nm Nd: YAG & fractional Co2 laser in the treatment of melasma by comparing patient satisfaction before treatment and after treatment and follow-p period. | 6 months to 1 year |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Melasma Area and Severity Index change. | Evaluate the role of additional fractional co2 laser to the previously Q switched Nd: YAG treated melasma patients by measuring changes in modified MASI score before treatment and after treatment and follow-p period. | 6 months to 1 year |
| Melanin index change. |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo University Kasr Al Ainy Hospital Dermatology department | Cairo | El Manial | Egypt |
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| ID | Term |
|---|---|
| D008548 | Melanosis |
| ID | Term |
|---|---|
| D017495 | Hyperpigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| Fractional CO2 laser | Device | Laser device emitting fractionated ablative laser aiming for skin resurfacing |
|
Evaluate the role of additional fractional co2 laser to the previously Q switched Nd: YAG treated melasma patients by taking spectrophotometer readings (melanin index) before treatment and after treatment and follow-p period. |
| 6 months to 1 year |
| percentage of clinical improvement | Evaluate the role of additional fractional co2 laser to the previously Q switched Nd: YAG treated melasma patients by comparing the results of masked dermatologists' observation of clinical photographs before treatment and after treatment and follow-p period. | 6 months to 1 year |
| patient satisfaction rate | Evaluate the role of additional fractional co2 laser to the previously Q switched Nd: YAG treated melasma patients by comparing patient satisfaction before treatment and after treatment and follow-p period. | 6 months to 1 year |