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This study aims to assess the efficacy and safety of using combination of 755-nm picosecond alexandrite laser and 2% hydroquinone compared with 2% hydroquinone alone for the treatment of melasma: A randomized split-face controlled trial
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| split face - left side | Experimental |
| |
| split face - right side | Active Comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 755-nm picosecond alexandrite laser with topical 2% hydroquinone | Device | treatment one side of the face with 755-nm picosecond alexandrite laser with topical 2% hydroquinone |
|
| Measure | Description | Time Frame |
|---|---|---|
| Modified melasma area and severity index score(mMASI) - comparing between Picosecond laser 755 nm with 2%HQ and 2%HQ alone for treatment of melasma of using combination of 755-nm picosecond alexandrite laser and 2% hydroquinone | score range 0-24 | 6 months |
| Melanin index measured by Mexameter® - comparing between Picosecond laser 755 nm with 2%HQ and 2%HQ alone for treatment of melasma | measuring in au | 6 months |
| Average melanin measured by Antera3D® - comparing between Picosecond laser 755 nm with 2%HQ and 2%HQ alone for treatment of melasma | measuring in au | 6 months |
| Patient satisfaction quartile score - comparing between Picosecond laser 755 nm with 2%HQ and 2%HQ alone for treatment of melasma | score 0 -100% | 6 months |
| Physician evaluation quartile score - comparing between Picosecond laser 755 nm with 2%HQ and 2%HQ alone for treatment of melasma | score 0 -100% | 6 months |
| Measure | Description | Time Frame |
|---|---|---|
| Safety of using combination of 755-nm picosecond alexandrite laser | Monitor side effect from picesecond alexandrite laser | 6 months |
| Safety of using 2% hydroquinone | side effect of topical 2%Hydroquinone use |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| woraphong Manuskiatti, M.D. | Contact | 02-419-1000 | doctorlaser@gmail.com | |
| Chadakan Yan, M.D. | Contact | 66882334090 | chadakanyan4090@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Dermatology, Siriraj Hospital, Mahidol University | Recruiting | Bangkok | 10700 | Thailand |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 36345697 | Derived | Manuskiatti W, Yan C, Gulfan MCB, Techapichetvanich T, Wanitphakdeedecha R. Combination of a 755-nm picosecond laser and hydroquinone 2% cream versus hydroquinone 2% cream alone for the treatment of melasma: A randomized, split-face, and controlled trial. Lasers Surg Med. 2022 Dec;54(10):1245-1250. doi: 10.1002/lsm.23615. Epub 2022 Nov 8. |
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| topical 2% hydroquinone | Drug | treatment one side of the face with topical 2% hydroquinone |
|
| 6 months |
| ID | Term |
|---|---|
| D008548 | Melanosis |
| ID | Term |
|---|---|
| D017495 | Hyperpigmentation |
| D010859 | Pigmentation Disorders |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| C031927 | hydroquinone |
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