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| Name | Class |
|---|---|
| Luzerner Kantonsspital | OTHER |
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Multi-centre clinical follow-up study on patients with a history of acute haematogenous osteomyelitis and/or septic arthritis. The aim is to describe the frequency of sequelae in these former patients with osteoarticular infections. Patients will be invited to participate in a single follow-up visit including a standardised interview and a clinical examination. The collected data will be analyzed together with data from the patient's hospital stay.
Clinical follow-up study on patients with a history of acute haematogenous osteomyelitis and/or septic arthritis and were admitted to one of the participating centres between 2005 and 2014.
Former patients will be invited to participate in a single-follow-up visit which comprises a standardised interview (pain, disabilities in daily life and regarding sports) and a standardized clinical examination of the previously affected body part. This includes assessment of range of motion in affected and adjacent joints and in case of previously affected lower extremity leg axis, gait and body height (percentile).
The data collected during the follow-up visit will be analyzed in a descriptive manner together with data of the patient's hospital stay including baseline data, laboratory works, microbiological results and both antibiotic and surgical treatment.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention, only clinical examination | Other | standardised interview and clinical examination |
| Measure | Description | Time Frame |
|---|---|---|
| subjective sequelae score of previously affected body region: lower extremity | Assessment of current pain and ability to perform physical activities summarized in a Subjective Sequelae Score modified after the PODCI (Pediatric Outcomes Data Collection Instrument) questionnaire and score: Lower Extremity: 11 Questions, Points 0-35, 0 = no disabilities, 1-11 = minor disability, 12-23 = moderate disability, 24-35 = severe disability Question 1: Current pain: (0-5 Points: never/less than once a month/once a month/once a week/more than once a week/daily) Questions 2-11 (0-3 Points never/less than once a month/once a month/once a week/more than once a week/daily) 2) Short distance running 3) Long distance running 4) Walking > 100m 5) Walking > 1000m 6) Climbing stairs 7) Walking uphill 8) Walking downhill 9) Participation in ball games/sports 10) Kneeling down 11) Sitting low (e.g. car, couch) | Day 1 (at single study visit) |
| subjective sequelae score of previously affected body region: upper extremity | Assessment of current pain and ability to perform physical activities summarized in a Subjective Sequelae Score modified after the PODCI (Pediatric Outcomes Data Collection Instrument) questionnaire and score: Upper Extremity: 6 Questions, Points 0-35, 0 = no disabilities, 1-6 = minor disability, 7-13 = moderate disability, 14-20 = severe disability Question 1: Current pain: (0-5 Points: never/less than once a month/once a month/once a week/more than once a week/daily) Questions 2-6 (0-3 Points never/less than once a month/once a month/once a week/more than once a week/daily) 2) Light work with upper body 3) Heavy work (e.g. Lifting heavy things) 4) Using Tools 5) Putting weight on upper body 6) Overhead work | Day 1 (at single study visit) |
| relevant restricted range of motion | restricted range of motion of > 20° of previously affected body part / joint compared to the other side | Day 1 (at single study visit) |
| Measure | Description | Time Frame |
|---|---|---|
| asymmetric axis of leg or arm | asymmetric leg or arm axis of previously affected lower or upper limb, respectively. | Day 1 (at single study visit) |
| limb length discrepancy of > 1cm | asymmetric length of legs/arms of previously affected lower or upper limb, respectively. |
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Inclusion Criteria:
Exclusion Criteria:
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Former patients admitted to one of the participating centres for an acute osteoarticular infection.
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| Name | Affiliation | Role |
|---|---|---|
| Nora Manz, MD | University Children's Hospital Basel | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University Children's Hospital Basel | Basel | Canton of Basel-City | 4056 | Switzerland | ||
| Children's Hospital Lucerne |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29728840 | Background | Manz N, Krieg AH, Heininger U, Ritz N. Evaluation of the current use of imaging modalities and pathogen detection in children with acute osteomyelitis and septic arthritis. Eur J Pediatr. 2018 Jul;177(7):1071-1080. doi: 10.1007/s00431-018-3157-3. Epub 2018 May 4. | |
| 33335875 | Derived | Manz N, Krieg AH, Buettcher M, Ritz N, Heininger U. Long-Term Outcomes of Acute Osteoarticular Infections in Children. Front Pediatr. 2020 Nov 25;8:587740. doi: 10.3389/fped.2020.587740. eCollection 2020. |
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| ID | Term |
|---|---|
| D001170 | Arthritis, Infectious |
| ID | Term |
|---|---|
| D007239 | Infections |
| D001168 | Arthritis |
| D007592 | Joint Diseases |
| D009140 | Musculoskeletal Diseases |
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| Day 1 (at single study visit) |
| abnormal gait (only in case of previously affected lower limb) | abnormal gait (e.g. limping) at examination | Day 1 (at single study visit) |
| z-score decline of body height since hospital discharge (only in case of previously affected lower limb) | decline in body height between hospital discharge and study visit | variable, between 4 and 14 years, depending on time frame between date of discharge and today's study visit. |
| Lucerne |
| 6000 |
| Switzerland |