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Temporary suspended. Wait for IRB approval (inclusion duration modified)
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This is an ambispective observational study of patients admitted to intensive care with a diagnosis of joint prosthesis infection (mainly knee and hip prostheses). The main objective of the study is to describe the profile, care trajectories during the stay (before or after surgery) and prognosis of patients admitted to critical care with such an infection. We also aim to compare prognosis between different groups of patients sharing the same profile and care trajectory, and to assess independent risk factors associated with 2-year mortality among the study population. Finally, we will describe the microbiological and resistance profile of severe osteoarticular device infections requiring critical care admission in France.
This is a descriptive and analytical observational study open to all French public and private hospitals.
Patient data will be retrieved prospectively from patient source files. Only 2-year data (vital status, functional data) will be collected specifically for the study, by telephone contact with the patient or his or her support person.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Global cohort | All patients admitted to intensive care during the study period |
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| Measure | Description | Time Frame |
|---|---|---|
| The profile, trajectories of care during the stay (before or after surgery) and the prognosis of patients admitted to intensive care for joint prosthesis infection over a 2-year period after admission to intensive care. | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Composite endpoint reflecting poor clinical outcome |
| 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Critical care patients (intensive care and continuing care), admitted between 2018 and 2022 with a principal or associated diagnosis of prosthetic joint infection.
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| Name | Affiliation | Role |
|---|---|---|
| Carine PARE | Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Lariboisière | Paris | France | 75010 | France |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Mortality at 2 years |
| 2 years |
| Description of pathogens found in intraoperative samples, and their resistance spectrum | 2 years |
| D013568 |
| Pathological Conditions, Signs and Symptoms |