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This is an observational, retrospective, multicenter study based on the use of demographic, clinical and biological data from deceased patients admitted between 2018 and 2022 to critical care with a principal or associated diagnosis of joint prosthesis infection.
Data from this study will be combined with that from the OASIS study (APHP241174/ ID-RCB: 2024-A01769-38) concerning osteoarticular sepsis on prosthetic material in critical care of living patients.
The aim of this study is to improve our knowledge of the profile, care trajectories and outcomes of patients hospitalized in critical care in the context of osteoarticular material sepsis.
The results of the study could help identify at-risk populations and improve management strategies for patients with osteoarticular sepsis.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Global cohort | Other | All deceased patients admitted to intensive care during the study period and satisfying the eligibility criteria. |
| Measure | Description | Time Frame |
|---|---|---|
| Epidemiological description of deceased patients | Demographic data, medical history, history of Periprosthetic Joint Infection (timing, diagnosis, surgery, antibiotics), data in intensive care unit (leng of stay, organ failure, drugs and mechanical support, biological data) and outcome (time of death within 2 years after admission to Intensive Care Units). | 2 years |
| Measure | Description | Time Frame |
|---|---|---|
| Composite endpoint reflecting poor clinical outcome |
| 2 years |
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Inclusion Criteria:
Exclusion Criteria:
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Critical care patients (intensive care and continuing care), admitted between 2018 and 2022 with a principal or associated diagnosis of joint prosthesis infection, who have since died.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Benjamin SOYER, MD, Msc | Contact | +33 1 49 95 85 15 | benjamin.soyer@aphp.fr | |
| Benjamin CHOUSTERMAN, MD, PhD | Contact | benjamin.chousterman@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Carine PARE | Assistance Publique - Hôpitaux de Paris | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Hôpital Lariboisière | Recruiting | Paris | France | 75010 | France |
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| ID | Term |
|---|---|
| D018805 | Sepsis |
| ID | Term |
|---|---|
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
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| Mortality at 2 years |
| 2 years |
| Epidemiological description based on the number (n) and proportion (%) of bacterial strains found in samples collected during the operation. | Special focus on: Gram-positive bacteria (Staphylococcus, Streptococcus, Enterococcus), Gram-negative bacteria (Enterobacteriacea, Pseudmononas), slow-growing bacteria (Cutibacterium, Corynenbacteria), yeasts; resistance mechanisms (meticillin, rifampicin, quinolone, glycopeptide, ESBL, carbapenem). | 2 years |
| D013568 |
| Pathological Conditions, Signs and Symptoms |