Humidified Culture and Live Birth After ICSI

Humidified Incubator Effect on Live Birth Rate After ICSI

Humidity for human embryo culture has been raised as essential with advantageous effect on clinical pregnancy and ongoing pregnancy after ICSI compared with a dry incubator. Whether the deleterious effect of dry culture would have an extended effect reaches the live birth rate needs to be examined. This RCT is to examine the effect of dry and humidified culture on live birth rates after ICSI.

Inclusion Criteria:

• Women undergoing a first or second ICSI attempts
• Primary or secondary infertility with a BMI of < 31 kg/m2
• Duration of infertility of ≥ 18 months and normal baseline ultrasonography
• 18 to 40 years of age
• Tubal factor, male factor, polycystic ovary, unexplained infertility or combined factors
• Tubal factors

Exclusion Criteria:

• Surgically-retrieved, frozen-thawed and pinpoint sperm or globozoospermia
• Thin endometrium
• Uterine anomaly and adhesion
• Adenomyosis
• Submucous myoma
• Endometriosis
• Severe medical condition