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| Name | Class |
|---|---|
| Banoon IVF Center | OTHER |
| Quena IVF Center | UNKNOWN |
| Amshag IVF Center | UNKNOWN |
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Humidity for human embryo culture has been raised as essential with advantageous effect on clinical pregnancy and ongoing pregnancy after ICSI compared with a dry incubator. Whether the deleterious effect of dry culture would have an extended effect reaches the live birth rate needs to be examined. This RCT is to examine the effect of dry and humidified culture on live birth rates after ICSI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Culture of human embryo in non-humidified incubator | Experimental | Embryo culture after in vitro fertilization in incubator with no humidity |
|
| Culture of human embryo in humidified incubator | No Intervention | Embryo culture after in vitro fertilization in incubator with humidity |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Human embryo culture | Other | humidifed or dry incubator |
|
| Measure | Description | Time Frame |
|---|---|---|
| Live birth rate | Viable neonate after 30 weeks of gestation per initiated cycle | 30 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Cumulative live birth rate | Viable neonate after 30 weeks of gestation after one fresh and/or one frozen-warmed transfer per initiated cycle | One year |
| Ongoing pregnancy rate | Continued pregnancy after 12 weeks of gestation per initiated cycle |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qena Fertility Center | Qina | Qena Governorate | 123456 | Egypt | ||
| Banon Assiut |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| 12 weeks of gestation |
| Cumulative ongoing pregnancy rate | Continued pregnancy after 12 weeks of gestation per initiated cycle within one year of randomization | 12 weeks of gestation |
| Clinical pregnancy rate | Ultrasound detect heartbeat after 7 weeks of gestation per initiated cycle | 7 weeks of gestation |
| Cumulative clinical pregnancy rate | Ultrasound detect heartbeat after 7 weeks of gestation per initiated cycle within one year of randomization | 7 weeks of gestation |
| Implantation rate | Number of sacs with a heartbeat per number of embryo transferred | 7 weeks of gestation |
| Cumulative implantation rate | Number of sacs with a heartbeat per number of embryo transferred within one year of randomization | 7 weeks of gestation |
| Ongoing implantation rate | Number of sacs with a heartbeat per number of embryo transferred | 12 weeks of gestation |
| Cumulative ongoing implantation rate | Number of sacs with a heartbeat per number of embryo transferred within one year of randomization | 12 weeks of gestation |
| Preterm birth rate | number of babies born before 37 weeks of gestation per total birth | 37 weeks |
| Very preterm birth | number of babies born before 32 weeks of gestation per total birth | 32 weeks |
| Low birth weight rate | number of babies with < 2500 gm per total birth | 40 weeks of gestation |
| Fertilization rate | fertilized oocytes with two pronuclei per Metaphase II injected | 6 days of culture |
| Cleavage rate | Cleaved embryo per fertilized oocyte | 6 days of culture |
| Rate of high-quality day-3 embryos | Embryos with seven or eight blastomeres of appropriate-size, and < 10% fragmentation by volume per fertilized oocyte | 6 days of culture |
| Blastocyst formation rate | Formed blastocyst on day 5/6 from fertilized oocytes | 6 days of culture |
| Rate of high-quality blastocyst | Blastocysts ≥ 3.1.1 grade per fertilized oocyte | 6 days of culture |
| Rate of utilizable blastocyst | Transferred and cryopreserved blastocysts from fertilized oocytes | 6 days of culture |
| Asyut |
| Egypt |
| IbnSina IVF Center | Sohag | Egypt |