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| ID | Type | Description | Link |
|---|---|---|---|
| ibnsinaH | Other Identifier | ibnsinaH |
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| Name | Class |
|---|---|
| Ganna Hospital | OTHER |
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To compare Top quality embryos either day3 or day 5, Pregnancy rate and most importantly ongoing pregnancy rate between high humidity incubators and humidity free incubators
When the IVF started the majority of incubators designed to support high humidity because the designers and IVF specialists believed that the humidity will maintain stable ph and Temp.
Recent reports suggest that humidity is recommended and the others suggest no difference So we decide to go for this RCT. Nevertheless; high humidity is maintained in vivo (uterus and fallopian tubes) due to the fluid content and stable body temperatures at 37°C. David McCulloch reported 15% reduction of the miscarriage rate after changing the humidity from 76% to 100% (Textbook of Assisted Reproductive Techniques: Laboratory Perspectives, Fourth Edition). Some embryologists claim that the humidity free incubators may increase the chance of chemical pregnancy and early fetal loss (Private center IbnSina IVF, Sohag, Egypt. unpublished data). This observations are never tested in a well designed randomized clinical trial (RCT) to eliminate the probability of chance and to reach a solid evidence.
The question that should be asked : is high humidity culture should be applied or there is no difference between dry and high humidity culture conditions?
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| The Embryos will be cultured on a humidity free incubator | Experimental | We will set the humidity level to 0.0% in the IVF incubator that will be used for culturing the Human embryos after ICSI procedure and we will monitor the outcome embryologically and clinically and record the results. |
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| The Embryos will be cultured on a >95% humidity incubator | Placebo Comparator | We will set the humidity level to > 95% in the IVF incubator that will be used for culturing the Human embryos after ICSI procedure and we will monitor the outcome embryologically and clinically and record the results. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| The Embryos will be cultured on a humidity free incubator | Other | We will set the humidity level to 0.0% in the IVF incubator that will be used for culturing the Human embryos after ICSI procedure and we will monitor the outcome embryologically and clinically and record the results. |
| Measure | Description | Time Frame |
|---|---|---|
| Ongoing pregnancy rate | assessing the ongoing pregnancy rate and its difference between the 2 study arms. | 18 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Muhammad F. Abdel-Raheem, Lab Director | IBNSINA IVF Center | Principal Investigator |
| Muhammad El Hady, Lab Director | Ganna Hospital | Principal Investigator |
| Mohamed Y. Abdel-Rahman, M.D. | IBNSINA IVF center | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Gannah IVF unit, Gannah Hospital | Giza | Giza Governorate | 12345 | Egypt | ||
| IbnSina IVF unit, IbnSina Hospital, El Areef Square |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28651960 | Derived | Fawzy M, AbdelRahman MY, Zidan MH, Abdel Hafez FF, Abdelghafar H, Al-Inany H, Bedaiwy MA. Humid versus dry incubator: a prospective, randomized, controlled trial. Fertil Steril. 2017 Aug;108(2):277-283. doi: 10.1016/j.fertnstert.2017.05.036. Epub 2017 Jun 23. |
| Label | URL |
|---|---|
| Facebook group for Gannah hospital, site doing the study | View source |
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| The Embryos will be cultured on a >95% humidity incubator | Other | We will set the humidity level to 95% in the IVF incubator that will be used for culturing the Human embryos after ICSI procedure and we will monitor the outcome embryologically and clinically and record the results. |
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| Sohag |
| Sohag Governorate |
| 12345 |
| Egypt |