Fasting and Exercise-induced Changes in Human Skeletal Muscle

Impact of Exercise-induced Energetic Stress During an 8-hour Fast on Metabolic Regulation in Resting Human Skeletal Muscle

This study examines the impact of increasing energetic stress during an 8-hour fast on metabolic pathways in human skeletal muscle. Specifically, participants will undergo two 8-hour fasting sessions in a randomized crossover fashion, with the addition of low-intensity arm exercise in one of the sessions. Changes in metabolic pathways will be examined in resting (leg) muscle before, during, and after the fast.

Inclusion Criteria:

• recreationally active (no more than 3 hours of weekly physical activity)
• not currently involved in a systematic training program
• body mass index < 30 kg/m2

Exclusion Criteria:

• presence of cardiometabolic disease
• taking regular oral medication
• current smoker