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Hypothesis: during fasting and exercise will there be an activation of sirtuins (Sirt1).
Primarily the investigators will investigate Sirt1 activity in muscle- and fat-biopsies after fasting for 36 hours and after 1 hour of ergometer-cycling at 50 Vo2max.
In addition to this the investigators will investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| fasting and exercise | Experimental | 36 h fast and 1 h ergometer cycling 50% VO2max |
|
| exercise | Experimental | 1 h ergometer cycling 50% VO2max |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| fast and exercise | Other | fasting 36 h and exercise 1 h 50% VO2max |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Sirt1 activity | 60 min |
| Measure | Description | Time Frame |
|---|---|---|
| secondary will we investigate the effect of fasting and exercise on the velocity of carbamide synthesis, aminoacid rate of turnover and glucose rate of turnover. | 4 h |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| mikkel Holm Vendelbo | Aarhus | Jylland | 8000 | Denmark |
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| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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| exercise |
| Other |
exercise 1 h 50% VO2max |
|