Short Course Radiation Therapy in Palliative Treatment of Thoracic Cancer

SHort Course Accelerated RadiatiON Therapy (SHARON) in Palliative Treatment of Thoracic Cancer: an Interventional, Randomized, Multicentric Study

Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic thoracic malignant lesions

Standard treatment for thoracic lesions (3000 cGy in 10 daily fractions of 300 cGy each) is compared with experimental treatment (2000 cGy in 4 fractions of 500 cGy twice a day) to demonstrate non-inferiority of this scheme

Inclusion Criteria:

• symptomatic thoracic malignant lesions (primary solid tumors or metastases from solid tumor)
• age> 18 years
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-3
• no changes in supportive care in the week before radiotherapy

Exclusion Criteria:

• pregnancy
• previous irradiation of the same region