Short Course Radiation Therapy in Palliative Treatment of Complicated Bone Metastases

SHort Course Accelerated RadiatiON Therapy (SHARON) in Complicated Bone Metastases Palliation: an Interventional, Randomised, Multicentric Study

Aim of the study is to assess efficacy of a short course radiation treatment in patients with complicated bone metastases

Standard treatment for complicated bone metastases (3000 cGy in 10 daily fractions of 300 cGy each) is compared with experimental treatment (4000 cGy in 4 fractions of 500 cGy twice a day) to demonstrate non-inferiority of this scheme.

Inclusion Criteria:

• complicated bone metastases from any solid tumor
• age >18 years
• ECOG performance status 0-3
• symptomatic lesion (NRS >1)
• no changes in analgesic treatment at least in the week before radiotherapy

Exclusion Criteria:

• pregnancy
• previously irradiation of the same region