Short Course Radiation Therapy in Palliative Treatment of Pelvic Cancer

SHort Course Accelerated RadiatiON Therapy (SHARON) in Palliative Treatment of Pelvic Cancer: an Interventional, Randomized, Multicentric Study

Aim of the study is to assess efficacy of a short course radiation treatment in patients with symptomatic pelvic malignant lesions

standard treatment for pelvic lesions (300 cGy in 10 daily fractions of 300 cGy each) is compared with experimental treatment (2000 cGy in 4 fractions of 500 cGy twice a day) to demonstrate non-inferiority of this scheme

Inclusion Criteria:

• symptomatic pelvic malignant lesions (primary solid tumors or metastases from solid tumor)
• age > 18 years
• Eastern Cooperative Oncology Group (ECOG) Performance Status 0-3
• no changes in supportive care in the week before radiotherapy

Exclusion Criteria:

• pregnancy
• previous irradiation of the same region