Impact of Oligonol to Cardiometabolic Risk and Muscular Health

Impact of Oligonol to Cardiometabolic Risk and Muscular Health: a Randomized Controlled Trial

This project will mainly focus on Middle and old-aged adults, and examine whether Cardiovascular and metabolic risks can be reduced. In the meanwhile, this project will develop strategies for improving muscle loss , muscle strength decline, and the quality life of the elderly.

Cardiovascular diseases are common among the elder. However, previous researches mainly focus on observational research or small scale clinical trial, and the subjects are mainly youth. Therefore, this project hope to understand whether Oligonol can reduce Cardiovascular and metabolic risks among senior adults. Consequently,improve muscle loss muscle strength decline, quality of old adults life. This project design may potentially develop new strategies for curing Sarcopenia as well.

Inclusion Criteria:

• People who aged more than 50 years
• Patients with following characteristics:
• feeling loss in activity.
• detecting decline in self's walking speed.
• feeling tired of doing everything.
• having fallen down last year.
• People can accept undergoing MRI
• People willing to follow the program and cooperate with us for following tracking.
• People who are neither vegan nor vegetarian

Exclusion Criteria:

• Walking speed less than 0.3m/s
• People with any disease affecting their limbs, including:
• having fracture on limbs in the past 6 months.
• having severe arthritis in the past 6 months
• any other whom PI recognized as weak control of their nervous system( e.g.: Parkinson's disease and stroke).
• People with intermittent limp caused by peripheral artery diseases
• People with weak control of mental disorder
• People with weak control of Cardiopulmonary disease
• People with weak control of Malignant tumor
• People with weak control of kidney diseases (GFR < 30 mL/min/1.73 m2 for at least 3 months)
• People with visual impairment and hearing disorder who cannot complete the program.
• People who are unable to undertake MRI
• Any other condition that PI recognized as not suitable.