| Primary | Plasma Concentration of D-lactic Acid Before the Surgery | The level of D-lactic acid can indicate the damage to the gastrointestinal barrier . | | Posted | | Mean | Standard Deviation | ng/ml | | 1 day before the surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
| | | Title | Denominators | Categories |
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| | | Title | Measurements |
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| - OG0001100.4± 156.6
- OG0011087.8± 146.0
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| Primary | Plasma Concentration of Diamine Oxidase (DAO) Before the Surgery | The level of DAO can indicate the damage to the gastrointestinal barrier . | | Posted | | Mean | Standard Deviation | U/L | | 1 day Before the Surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Primary | Total Number of Operational Taxonomic Units (OUTs) of Intestinal Microbiota | Intestinal microbiota was analyzed by 16S rRNA sequencing. To be specific, first, DNA was extracted and quantified. Bacterial 16S rRNA genes of the V3-V4 region were amplified from extracted DNA using the barcoded primers (5'- CCTACGGRRBGCASCAGKVRVGAAT-3') and (5'- GGACTACNVGGGTWTCTAATCC-3'). PCR reactions were performed and the PCR mixture applied to the PCR amplifier. Then, the PCR products were checked for size and specificity by agarose gel electrophoresis and purified. Finally, high-throughput sequencing was performed using the Illumina MiSeq platform. The raw reads were filtered to remove low quality sequences and the filtered data were further merged into tags by FLASH(Version 1.2.7). Then the Uchime algorithm in Usearch software was applied to remove chimeric tags. Resulting tags for each sample were clustered into operational taxonomic units(OTUs) at the level of 97% similarity. Higher values represent a more abundant amount of bacteria in gut. | There were only 8 patients in group D and 5 patients in group M defecating before discharged from hospital. | Posted | | Number | | units | | the first time of defecation after operation | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) |
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| Primary | Postoperative Exhaust Time | It's a regular measurement to evaluate the function of gastrointestinal tract . It is calculated from the end of the operation to the time of exhaust. | | Posted | | Mean | Standard Deviation | hour | | It is calculated from the end of the operation to the time of exhaust. | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Primary | Plasma Concentration of D-lactic Acid 24 h After the Surgery | The level of D-lactic acid can indicate the damage to the gastrointestinal barrier . | | Posted | | Mean | Standard Deviation | ng/ml | | 24 h after the surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Primary | Plasma Concentration of Diamine Oxidase (DAO) 24 h After the Surgery | The level of DAO can indicate the damage to the gastrointestinal barrier . | | Posted | | Mean | Standard Deviation | U/L | | 24 h after the Surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Primary | Relative Abundance of Intestinal Microbiota | Intestinal microbiota is one of the factors related to the recovery of intestinal function. It can be analyzed by 16S rRNA sequencing of the postoperative feces. | There were 8 patients group D and 5 patients in group M defecating before being discharged from the hospital. | Posted | | Median | Standard Deviation | percentage of all intestinal microbiota | | the first time of defecation after operation | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Primary | 16s rRNA Sequencing of Postoperative Feces | Alpha and Beta diversity; relative abundance of gut microbiota. Alpha diversity includes Chao 1 index, Shannon index, and Simpson index. A higher value of Chao 1 index corresponds to more abundant number of microbiota. A higher value of Shannon index corresponds to more abundance. And A higher value of Simpson index corresponds to less diversity. Bata diversity was assessed by PCoA analysis. A three dimensional scatter plot was presented to visualize the similarities and differences between the two groups. | There were 8 patients group D and 5 patients in group M defecating before being discharged from the hospital. There are so much basic data about the 16s rRNA sequencing that we can not upload them. The amount of work was formidable. You may contact with me if necessary for all the sequencing data. | Posted | | Mean | Standard Deviation | score on a scale | | the first time of defecation after operation | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade Group (Group D) | Patients undergoing elective laparoscopic surgery for gastrectomy will be randomized to receive deep neuromuscular blockade (post-tetanic count = 1-2) using high dose rocuronium. A continuous intravenous infusion of 0.5-0.6 mg/kg/h Rocuronium Bromide Intravenous Solution (50 Mg/5 mL) to keep the target neuromuscular blockade (PTC = 1-2).: 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.5-0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 |
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| Secondary | Duration of Surgery | Time from the first dose of anesthetic to the end of the surgery | | Posted | | Mean | Standard Deviation | minutes | | From the first dose of anesthetic to the end of the surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Surgical Condition Scores Rated by Surgeons | evaluation of the surgical condition by 5 point scale: 5 points: optimal; 4 points: good; 3 points: acceptable; 2 points: poor; 1 point: extremely poor. | | Posted | | Count of Participants | | Participants | | During operation, within 2 hours | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Duration of CO2 Pneumoperitoneum | Time from the beginning to the end of CO2 pneumoperitoneum | | Posted | | Mean | Standard Deviation | minute | | from the beginning to the end of CO2 pneumoperitoneum | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Duration of Postoperative Hospital Stay | Duration from the day of surgery to the day the patient discharged from the hospital | | Posted | | Mean | Standard Deviation | days | | from the end of surgery to the time of being discharged from hospital | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (12 h After Surgery, Rest State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | units on a scale | | 12 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (12 h After Surgery, Active State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | units on a scale | | 12 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (24 h After Surgery, Rest State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | points | | 24 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (24 h After Surgery, Active State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | units on a scale | | 24 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (48 h After Surgery, Rest State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | units on a scale | | 48 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Postoperative VAS (48 h After Surgery, Active State) | VAS pain score: 0 - completely painless, 10 - unbearable pain. | | Posted | | Mean | Standard Deviation | units on a scale | | 48 h after surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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| Secondary | Surgical Condition Scores Rated by Surgeons (Average Scores) | evaluation of the surgical condition by 5 point scale: 5 points: optimal; 4 points: good; 3 points: acceptable; 2 points: poor; 1 point: extremely poor. | | Posted | | Mean | Standard Deviation | units on a scale | | during surgery | | | | ID | Title | Description |
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| OG000 | Deep Neuromuscular Blockade（Group D） | 50 patients undergoing laparoscopic gastrectomy surgery will be allocated to group D. A continuous intravenous infusion of 0.6 mg/kg/h rocuronium to keep the target neuromuscular blockade (PTC = 1-2). | | OG001 | Moderate Neuromuscular Blockade (Group M) | 33 patients undergoing laparoscopic gastrectomy surgery will be allocated to group M. A continuous intravenous infusion of 0.2 mg/kg/h rocuronium to keep the target neuromuscular blockade (TOF = 1-2). |
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