The Laparotomy Study

Muscle Relaxation During Open Upper Abdominal Surgery - Can the Surgical Conditions be Optimized?

The depth of neuromuscular blockade (NMB) during surgery may cause a clinical dilemma between optimal surgical conditions and the risk of postoperative residual blockade.

The aim of the study is to investigate if intense NMB improves surgical conditions during operation in patients scheduled for elective open upper abdominal surgery.

Inclusion Criteria:

• Patients > 18 years old
• Elective open upper abdominal surgery
• Can read and understand Danish
• Informed consent

Exclusion Criteria:

• Known allergy to rocuronium or sugammadex
• Severe renal disease, defined by S-creatinine> 0.200 mmol/L, GFR < 30ml/min or hemodialysis
• Neuromuscular disease that may interfere with neuromuscular data
• Abdominal mesh with size larger than 5*5 cm
• Lactating or pregnant