To investigate the role of ATP sensitive K+ potassium channels and the Na+/K+ pump in the development of fatigue in healthy and in insulin resistant subjects.

Inclusion Criteria:

• Non smokers
• HbA1c <38 mmol/mol (<5.7%), HOMA-IR > 1.7 (insulin resistant)
• VO2max <40 ml/kg/min (insulin resistant), 45-55 ml/kg/m2 (healthy)
• BMI >26 kg/m2 (insulin resistant), 19-26 kg/m2 (healthy)

Exclusion Criteria:

• Use of antidiabetic medication or any other medication deemed to interfere with study outcomes
• Allergy towards Nicorandil
• Chronic disease other than type 2 diabetes deemed to interfere with study outcomes
• Excessive alcohol consumption (>14 units/week)
• Abnormal ECG