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The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acetazolamide | Experimental | Participants will be dosed 250mg acetazolamide (p.o.) three times per day for two days prior to and a single dose on the morning of the experimental day. |
|
| Methazolamide | Experimental | Participants will be dosed 100mg Methazolamide (p.o.) two times per day separated by a placebo dose for two days prior to and a single dose on the morning of the experimental day. The placebo dose is used to match the timing and number of pills taken between all arms of the study. |
|
| Placebo | Placebo Comparator | Participants will take three placebo pills per day for two days prior to and a single dose on the morning of the experimental day. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acetazolamide | Drug | 250 mg, taken orally three times per day |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Change in trans-diaphragmatic pressure generation to supramaximal phrenic nerve stimulation following inspiratory threshold loading. | Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study | |
| Change in plantar flexor muscle group torque generation to supramaximal tibial nerve stimulation following an isometric loading protocol | Baseline, 1, 5, 10, 20, and 30 minutes following the loading protocol for each arm of the study |
| Measure | Description | Time Frame |
|---|---|---|
| Maximal inspiratory pressure maneuvers | Baseline and immediately following loading protocol | |
| Maximal Voluntary Contraction of the Plantar Flexor Muscle Group | Baseline and immediately following the loading protocol |
| Measure | Description | Time Frame |
|---|---|---|
| Esophageal and Gastric Pressure | Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol | |
| Heart Rate | Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol | |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Glen E Foster, Ph.D. | University of British Columbia | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of British Columbia | Kelowna | British Columbia | V1V 1V7 | Canada |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29792554 | Result | Dominelli PB, McNeil CJ, Vermeulen TD, Stuckless TJR, Brown CV, Dominelli GS, Swenson ER, Teppema LJ, Foster GE. Effect of acetazolamide and methazolamide on diaphragm and dorsiflexor fatigue: a randomized controlled trial. J Appl Physiol (1985). 2018 Sep 1;125(3):770-779. doi: 10.1152/japplphysiol.00256.2018. Epub 2018 May 24. |
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| ID | Term |
|---|---|
| D000860 | Hypoxia |
| ID | Term |
|---|---|
| D012818 | Signs and Symptoms, Respiratory |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D000086 | Acetazolamide |
| D008704 | Methazolamide |
| ID | Term |
|---|---|
| D013830 | Thiadiazoles |
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
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| Methazolamide |
| Drug |
100mg, taken orally two times per day. A placebo pill will be taken between each dose of methazolamide to match the timing of doses and the number of pills between study arms. |
|
| Placebo | Other | A placebo will be taken three times per day |
|
| Contraction time and half-relaxation time | Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol |
| Beat-by-beat blood pressure |
| Baseline, 1, 5, 10, 20, and 30 minutes post loading protocol |
| D001393 |
| Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |