Muscle Fatigue and Carbonic Anhydrase Inhibitors

The Effect of Carbonic Anhydrase Inhibitors on the Pulmonary System Response to Muscle Fatigue.

The objective of this research is to assess the effects of acetazolamide and methazolamide on respiratory and limb muscle fatigue development. A fatiguing protocol will be conducted for the respiratory and plantar flexor muscles and the difference in pressure/torque produced by supramaximal nerve stimulation used to assess muscle fatigue between conditions.

Inclusion Criteria:

• Age: 18-40 years.
• Regularly physically active
• Male

Exclusion Criteria:

• current or ex-smokers
• pulmonary function <80% of predicted
• esophageal tumour or ulcer
• have had recent (<6 months) musculoskeletal injury or any surgery to the lower leg
• have contraindications to carbonic anhydrase inhibitors (eg. severe or absolute glaucoma, adrenocortical insufficiency, hepatic insufficiency, renal insufficiency, sulfa allergy or an electrolyte imbalance such as hyperchloremic acidosis)
• are obese (BMI >30 Kg/m2)
• taking diuretics, blood thinners, or anti-platelet drugs.