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Glaucoma is currently the leading cause of irreversible blindness in the world. The multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous from non-glaucomatous visual field, and to assess its utility in the real world.
Glaucoma is the world's leading cause of irreversible blind, characterized by progressive retinal nerve fiber layer thinning and visual field defects. Visual field test is one of the gold standards for diagnosis and evaluation of progression of glaucoma. However, there is no universally accepted standard for the interpretation of visual field results, which is subjective and requires a large amount of experience. At present, artificial intelligence has achieved the accuracy comparable to human physicians in the interpretation of medical imaging of many different diseases. Previously, we have trained a deep convolutional neural network to read the visual field reports, which has even higher diagnostic efficacy than ophthalmologists. The current multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous from non-glaucomatous visual field, compare its performance with ophthalmologists and to assess its utility in the real world.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| AI group | The visual field reports in this group will be evaluated by the convolutional neural network. |
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| Human group | The visual field reports in this group will be evaluated by 3 ophthalmologists independently. |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| AI diagnostic algorithm | Diagnostic Test | The visual fields collected would be assessed by the algorithm and ophthalmologists independently. The performance of the algorithm and the ophthalmologists would be compared, including accuracy, AUC, sensitivity and specificity. |
| Measure | Description | Time Frame |
|---|---|---|
| AUC value of convolutional neural network in differentiation of Glaucoma visual field from non-glaucoma visual field | from Jan 2019 to Jan 2020 |
| Measure | Description | Time Frame |
|---|---|---|
| Sensitivity and specificity of convolutional neural network in detection of glaucoma visual field | from Jan 2019 to Jan 2020 |
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Inclusion Criteria:
Exclusion Criteria:
Incomplete clinical data to support diagnosis
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Patients from clinics in different eye centers across China. Each subject must be diagnosed based on comprehensive medical tests and medical records. The leading center will read all the medical data to give out diagnosis as the gold standard.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Zhongshan Ophthalmic Center | Guangzhou | Guangdong | 51000 | China |
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| ID | Term |
|---|---|
| D005901 | Glaucoma |
| ID | Term |
|---|---|
| D009798 | Ocular Hypertension |
| D005128 | Eye Diseases |
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