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Reduced ambulatory activity has been shown to effect the response to a high fat tolerance test (HFTT) after acute exercise. This study will evaluate the effect of varying levels of daily ambulation on response to a HFTT after an acute aerobic exercise bout.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Very Low Steps | Experimental | Subjects will be asked to undergo reduced daily stepping to a level of 2,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour. |
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| Low Steps | Experimental | Subjects will be asked to undergo reduced daily stepping to a level of 5,000 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour. |
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| Moderate Steps | Experimental | Subjects will be asked to undergo reduced daily stepping to a level of 7,500 steps/d for 2 days. On the evening of day 2, they will be asked to run at 65% of VO2max for 1-hour. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Very Low Steps | Behavioral | Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Very Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides. |
| Measure | Description | Time Frame |
|---|---|---|
| 6-Hour Plasma Triglyceride Area Under the Curve | Areas under the curve for triglyceride concentration will be calculated for hourly samples from a 6-hour lipid tolerance test. | 6-hours |
| Measure | Description | Time Frame |
|---|---|---|
| 6-Hour Plasma Insulin Area Under the Curve | Areas under the curve for insulin concentration will be calculated for hourly samples from a 6-hour lipid tolerance test | 6-hours |
| 6-Hour Plasma Glucose Area Under the Curve |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Heath Burton, M.S. | University of Texas at Austin | Principal Investigator |
| Edward F Coyle, Ph.D. | University of Texas at Austin | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Texas at Austin Human Performance Laboratory | Austin | Texas | 78712 | United States |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33105387 | Derived | Burton HM, Coyle EF. Daily Step Count and Postprandial Fat Metabolism. Med Sci Sports Exerc. 2021 Feb 1;53(2):333-340. doi: 10.1249/MSS.0000000000002486. |
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| ID | Term |
|---|---|
| D050197 | Atherosclerosis |
| D024821 | Metabolic Syndrome |
| ID | Term |
|---|---|
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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Subjects will complete three experimental conditions which include 2 days of reduced step count (2,500, 5,000, and 7,500 steps/day) with 1-hour of exercise at 65% VO2max.
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|
| Low Steps | Behavioral | Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Low Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides. |
|
| Moderate Steps | Behavioral | Subjects will have a 2-day control period during which step count and diet will be controlled for and recreated for the other trials. Following this 2-day period, they will undergo the Moderate Stepping trial with the acute bout of exercise on day 2. Day 3 will consist of the lipid tolerance test to determine the ability of the body to clear triglycerides. |
|
Areas under the curve for glucose concentration will be calculated for hourly samples from a 6-hour lipid tolerance test.
| 6-hours |
| D007333 |
| Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |