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Studying the effect of music intervention on preterm infants' brain development by MRI and neurodevelopmental assessments
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Preterm music group | Experimental | Music exposure with headphones |
|
| Preterm control group | No Intervention | headphones without music | |
| Full-term control group | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Music | Other | Music created by A. Vollenweider at least 5 times per week from 33 weeks of gestational age until term-equivalent age |
|
| Measure | Description | Time Frame |
|---|---|---|
| Compare structural maturation in the three groups using structural MRI and DTI | An MRI will be conducted at term or term equivalent age including structural Magnetic Resonance Imaging and Diffusion Tensor Imaging (DTI) measures. | 40 weeks gestational age |
| Compare resting state maturation in the three groups using resting state fMRI | An MRI will be conducted at term or term equivalent age including resting state functional magnetic resonance imaging (fMRI) measures. | 40 weeks gestational age |
| Measure | Description | Time Frame |
|---|---|---|
| Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using fMRI | fMRI will be conducted in all three groups at term or term equivalent age | 40 weeks gestational age |
| Functional responses to known and unknown music in preterm infants with music intervention will be compared to no-intervention groups responses using EEG |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Petra S. Hüppi, Prof. | Contact | 0223824352 | +41 | petra.huppi@hcuge.ch |
| Lara Lordier, PhD | Contact | 0223725494 | +41 | lara.lordier@hcuge.ch |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Prof. Petra S. Hüppi | Recruiting | Geneva | 1211 | Switzerland |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37182337 | Derived | Sa de Almeida J, Baud O, Fau S, Barcos-Munoz F, Courvoisier S, Lordier L, Lazeyras F, Huppi PS. Music impacts brain cortical microstructural maturation in very preterm infants: A longitudinal diffusion MR imaging study. Dev Cogn Neurosci. 2023 Jun;61:101254. doi: 10.1016/j.dcn.2023.101254. Epub 2023 May 11. |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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| ID | Term |
|---|---|
| D009147 | Music Therapy |
| ID | Term |
|---|---|
| D026421 | Sensory Art Therapies |
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D012046 | Rehabilitation |
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High density Electroencephalography (EEG) will be conducted in all three groups at term or term equivalent age (mismatch negativity, Delta Brushes) |
| 40 weeks gestational age |
| The music intervention effect on cognitive language and motor development at one and two years of age | Bayley III Cognitive / Language (receptive / expressive) / Motor (fine / gross) Child's performance is compared with norms taken from typically developing children of their age (in months) | at 1 and 2 years of age |
| The music intervention effect on emotion and temperament at one and two years of age | LABoratory Temperament Assessment Battery (LabTAB) Four episodes:
| at 1 and 2 years of age |
| The music intervention effect on effortful control at one and two years of age | Effortful control battery Episodes: "Snack Delay", "Wrapped Gift", and "Tower". These episodes evaluate two components of effortful control: delaying (waiting for a pleasant event) twice and suppressing or initiating activity to signal (taking turns), respectively. | at 2 years of age |
| D000091642 | Urogenital Diseases |
| D000359 |
| Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D011613 | Psychotherapy |
| D004191 | Behavioral Disciplines and Activities |