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Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Latrunculin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Latrunculin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Handling Medium Supplemented with Latrunculin B | Experimental |
| |
| handling Medium as it is. | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Medium Supplemented with Latrunculin B | Other | A medium with in-house supplementation of Latrunculin B to decrease oocyte degeneration after ICSI and improve the survival rate |
|
| Measure | Description | Time Frame |
|---|---|---|
| oocyte survival rate after ICSI | 6 days of culture |
| Measure | Description | Time Frame |
|---|---|---|
| Fertilisation rate | 6 days of culture | |
| Rates of blastocyst formation and quality | Number of formed and high-quality blastocysts per fertilized oocytes | 6 days of culture |
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Inclusion Criteria:
Exclusion Criteria:
-
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Qena Fertility Center | Qina | Qena Governorate | 123456 | Egypt | ||
| Banon Assiut |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| ID | Term |
|---|---|
| C037068 | latrunculin B |
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| Clinical pregnancy rate | three months |
| Implantation rate | 7 weeks |
| Ongoing pregnancy rate | 12 weeks |
| Asyut |
| Egypt |
| IbnSina IVF Center, IbnSina Hospital | Sohag | 12345 | Egypt |