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| Name | Class |
|---|---|
| Banoon IVF Center | OTHER |
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Vienna Consensus has identified 10% damage rate after ICSI as a competency value. Despite the highest quality embryologists doing ICSI, degeneration sometimes occurs due to oocyte factors such as the fragile membrane, etc. Cytochalasin B serves to facilitate spindle or pronuclear transfer procedures helping to reduce the damage rate with no harm reported. Using Cytochalasin B during ICSI could serve to rescue some oocytes from the degeneration allowing for more chances of viable zygotes,
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Handling Medium Supplemented with Cytochalasin B | Experimental |
| |
| Handling Medium as it is. | No Intervention |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Cytochalasin B use in ICSI handling medium | Other | A medium with in-house supplementation of Cytochalasin B to decrease oocyte degeneration after ICSI and improve survival rate |
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| Measure | Description | Time Frame |
|---|---|---|
| oocyte survival rate | number of survived oocyte after intracytoplasmic sperm injection | 6 days of culture |
| Measure | Description | Time Frame |
|---|---|---|
| fertilization rate | number of fertilized oocytes per metaphase II injected | 6 days of culture |
| blastocyst formation rate | number of formed blastocyst per fertilized oocyte |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| IbnSina IVF Center | Sohag | Egypt |
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| ID | Term |
|---|---|
| D007246 | Infertility |
| ID | Term |
|---|---|
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
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| 6 days of culture |
| embryo utilization rate | number of embryo transferred added to number of those cryopreserved per fertilized oocyte | 6 days of culture |
| clinical pregnancy rate | number of women with a heartbeat at week 4 or more after embryo transfer | three months |
| ongoing pregnancy rate | number of women with continued pregnancy after twelve weeks of gestation | four months |