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The aim of the study is to examine symptomatology, quantitative sensory test (QST) parameters, muscle tenderness and muscle hardness in migraine patients interictally and compare with healthy controls
Migraine patients exhibit different symptomatology and responses to treatment. For example do many migraine patients have neck symptoms, despite they apparently do not have any neck disorders.Furthermore the response to treatment differs between patients. Differences in symptomatology, QST parameters and muscle stiffness can be used to subdivide and phenotype migraine patients.
The investigators are examining migraine patients with:
A semistructured interview, Quantitative sensory testing (cold pain threshold, heat pain threshold and Pin Prick), Muscle tenderness (total tenderness score, local tenderness score and stimulus response curve), and muscle hardness with ultrasound elastography. All tests are performed the same day
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Migraine patients | Migraine patients attending the Danish Headache Centre | ||
| Healthy Controls | Age and sex matched |
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| Measure | Description | Time Frame |
|---|---|---|
| Logistic regression model, Neck Stiffness | We would like to examine the relationship between the variable variable: Neck stiffness during migraine attack (Yes/No) and the Independent variables: Total Tenderness Score (summed score from 8 points bilateral, each point can score 0-3), Migraine localisation (occipital: Yes/No), Tension Type Headache, Allodynia (yes/No), Stimulus response curve (Pressure and Pain). The result shows how much of the variability in neck stiffness that can be explained by the independent variables. | 3 hours |
| Pericranial Muscle Tenderness | We will examine whether patients with neck stiffness during migraine attack (yes/no) have higher tenderness scores compared to patients without neck stiffness during migraine attacks, when correcting for headache frequency. | 3 hours |
| Muscle Hardness measured by ultrasound elastography | Muscle hardness (m/s) in migraine patients compared to healthy controls.corrected for age, BMI and sex | 3 hours |
| Muscle hardness measured by ultrasound elastography in migaine patients | Muscle hardness (m/s) in migraine patients with neck stiffness during migraine attacks compared to migraine patients without neck stiffness during migraine attacks. Corrected for age, BMI and sex. | 3 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Multiple Regression model, Total Tenderness Score | We would like to examine the relationship between the dependent variable: Total Tenderness Score(summed score from 8 points bilateral, each point can score 0-3), and the Independent variables: Neck Pain in general(Yes/No), Migraine localisation (occipital: Yes/No), Headache Frequency(days/month), Allodynia (Yes/No), Years with Migraine(Number of years) |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation analysis of muscle hardness and headache frequency | Muscle hardness will be measured with ultrasound elastography. Headache frequency is self-reported | 3 hours |
| Correlation analysis of muscle hardness and muscle tenderness assessed with the total tenderness score. |
Inclusion Criteria:
Exclusion Criteria:
Healthy controls:
Exclusion Criteria:
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Migraine patients are recruited from the out-patient clinic at the Danish Headache Center.
Healthy controls are recruited through web-sites.
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| Name | Affiliation | Role |
|---|---|---|
| Jeppe H Mann, MD | Danish Headache Center | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Danish Headache Center | Glostrup Municipality | 2600 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 32295400 | Derived | Hvedstrup J, Kolding LT, Ashina M, Schytz HW. Increased neck muscle stiffness in migraine patients with ictal neck pain: A shear wave elastography study. Cephalalgia. 2020 May;40(6):565-574. doi: 10.1177/0333102420919998. Epub 2020 Apr 15. |
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| ID | Term |
|---|---|
| D008881 | Migraine Disorders |
| D063806 | Myalgia |
| D051270 | Headache Disorders, Primary |
| D009422 | Nervous System Diseases |
| ID | Term |
|---|---|
| D020773 | Headache Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009135 | Muscular Diseases |
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| 3 hours |
| Logistic regression model, Neck pain in general | We would like to examine the relationship between the variable variable: Neck pain in general (Yes/No) and the independent variables: Tension Type Headache(yes/no), Migraine localisation, Headache Frequency(Headache days/month), Allodynia(yes/No), Years with Migraine(number of years) | 3 hours |
| Next migraine attack, Cox proportional hazards model | Using the prospective diary, we will examine the relationship between pericranial muscle tenderness and the next migraine attack, when correcting for headache frequency | 3 hours |
Muscle hardness will be measured with ultrasound elastography. |
| 3 hours |
| Correlation analysis of muscle hardness and pressure pain threshold assessed with an pressure algometer. | Muscle hardness will be measured with ultrasound elastography | 3 hours |
| D009140 |
| Musculoskeletal Diseases |
| D009468 | Neuromuscular Diseases |
| D059352 | Musculoskeletal Pain |
| D010146 | Pain |
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |