Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Evaluate the effect of propolis extract mouthwash and pomegranate extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.
This study will be carried out to evaluate and compare the effect of propolis extract mouthwash and pomegranate (botanical name: Punica granatum) extract mouthwash on taste alteration, salivary pH and antibacterial activity against streptococcus mutans in high caries risk patients.
Thats by taking unstimulated saliva samples at the morning before using the mouthwash, then taking another one after using the mouthwash and finally after 7 days, to make a bacterial culture and measure the salivary pH by a digital pH meter and evaluate taste changes by a questionnaire.
Not provided
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Propolis extract | Experimental | intervention |
|
| Pomegranate extract | Experimental | intervention |
|
| Chlorhexidine | Active Comparator | comparator |
|
| Saline | Placebo Comparator | comparator |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| chlorhexidine | Other | antibacterial and anti-inflammatory mouthwash |
|
| Measure | Description | Time Frame |
|---|---|---|
| Taste alteration | taste changes will be measured by a questionnaire | One week |
| Measure | Description | Time Frame |
|---|---|---|
| Salivary pH | salivary pH will be measured by digital pH meter | one week |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Type | Date | Date Unknown |
|---|---|---|
| Release | Nov 26, 2020 | |
| Reset | Dec 22, 2020 | |
| Release | Dec 22, 2020 | |
| Reset | Jan 14, 2021 |
Not provided
Not provided
| Release Date | Unrelease Date | Unrelease Date Unknown | Reset Date | MCP Release Number |
|---|---|---|---|---|
| Nov 26, 2020 | Dec 22, 2020 | |||
| Dec 22, 2020 |
| ID | Term |
|---|---|
| D003731 | Dental Caries |
| ID | Term |
|---|---|
| D017001 | Tooth Demineralization |
| D014076 | Tooth Diseases |
| D009057 | Stomatognathic Diseases |
Not provided
Not provided
| ID | Term |
|---|---|
| D002710 | Chlorhexidine |
| C543192 | hexitol |
| D012965 | Sodium Chloride |
| D000077330 | Saline Solution |
| D011429 | Propolis |
| C000712310 | pomegranate fruit rind |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
| D002712 |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
| saline | Other | anti-inflammatory cleansing mouthwash |
|
|
| Propolis extract | Other | antibacterial mouthwash |
|
| pomegranate extract | Other | antibacterial mouthwash |
|
| Jan 14, 2021 |
| Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D012116 | Resins, Plant |
| D001704 | Biopolymers |
| D011108 | Polymers |
| D046911 | Macromolecular Substances |
| D053147 | Plant Exudates |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |