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The mechanical control of supragingival biofilm is accepted as one of the most important measures to prevent dental caries and periodontal diseases. Nevertheless, maintaining dental surfaces biofilm-free is not an easy task. In this regard, numerous studies researches have demonstrated the effectiveness of mouthwashes containing antimicrobial active ingredients that prevent and control both supragingival biofilm and gingivitis, specially when used adjunctively to mechanical oral hygiene regimens.
In vitro and clinical researches using Punica granatum Linn shows antimicrobial and antiadherent activity against dental biofilm microorganisms. The purpose of this study was to evaluate the clinical effectiveness of a mouthwash of Punica granatum Linn. against biofilm and gingival inflammation in school children
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Punica granatum Linn. | Experimental | The childrens used the mouthwash contain pomegranate 6,25% twice daily for 14 days. |
|
| chlorhexidine | Active Comparator | The childrens used the mouthwash contain chlorhexidine 0.12% twice daily for 14 days. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Punica granatum Linn. | Drug | Mouthwash (6,25% of Punica granatum Linn) 10mL per day during 14 days |
|
| Measure | Description | Time Frame |
|---|---|---|
| Difference in the Gingival Index scores. | On day 0, we measured the Plaque Index (PI) (Silness; Löe, 1964) at baseline, on the seventh day and on the fourteenth day. | Baseline, Seventh Day and Fourteeth day (14 days) |
| Difference in the Gingival Bleeding Index scores. | On day 0, we measured the Bleeding on Probing Index (BPI) (Ainamo; Bay, 1975) at baseline, on the seventh day and on the fourteenth day. | Baseline, Seventh Day andFourteeth day (14 days) |
| Difference in the Microbiological analysis of saliva for oral streptococcus count evolution from the start till the end of the study. | At baseline, we collected non-stimulated saliva samples into a sterile container for counting of oral streptococci in the laboratory. And on the fourteenth day, we carried out the second saliva collection and measured the clinical indices used. | Baseline and Fourteeth day (14 days) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| DANÚBIA RM NÓBREGA, Mastering | Universidade Estadual da Paraiba | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Universidade Estadual Da Paraiba | Campina Grande | ParaÃba | 58.429-500 | Brazil |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 17182487 | Background | Menezes SM, Cordeiro LN, Viana GS. Punica granatum (pomegranate) extract is active against dental plaque. J Herb Pharmacother. 2006;6(2):79-92. | |
| 21206931 | Background | Bhadbhade SJ, Acharya AB, Rodrigues SV, Thakur SL. The antiplaque efficacy of pomegranate mouthrinse. Quintessence Int. 2011 Jan;42(1):29-36. |
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| ID | Term |
|---|---|
| D005891 | Gingivitis |
| D003773 | Dental Plaque |
| ID | Term |
|---|---|
| D007239 | Infections |
| D005882 | Gingival Diseases |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
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| ID | Term |
|---|---|
| D002710 | Chlorhexidine |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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| chlorhexidine | Drug | standard anti-bacterial mouthwash Mouthwash (0,12% chlorhexidine) 10mL per day during 14 days |
|
|
| 19170139 | Background | DiSilvestro RA, DiSilvestro DJ, DiSilvestro DJ. Pomegranate extract mouth rinsing effects on saliva measures relevant to gingivitis risk. Phytother Res. 2009 Aug;23(8):1123-7. doi: 10.1002/ptr.2759. |
| 17262129 | Background | Vasconcelos LC, Sampaio FC, Sampaio MC, Pereira Mdo S, Higino JS, Peixoto MH. Minimum inhibitory concentration of adherence of Punica granatum Linn (pomegranate) gel against S. mutans, S. mitis and C. albicans. Braz Dent J. 2006;17(3):223-7. doi: 10.1590/s0103-64402006000300009. |
| D009057 |
| Stomatognathic Diseases |
| D003741 | Dental Deposits |
| D014076 | Tooth Diseases |