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To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition.
To evaluate the clinical effectiveness of mouthwash containing pomegranate peel extract and chlorhexidine mouthwash on bleeding on brushing and counting of streptococcus mutans among a group of Egyptian children with permanent dentition.
PICO:
Population (P): Children with full permanent dentition. Intervention (I): Pomegranates peel extract. Comparator (C): Chlorhexidine.
Outcome(O):
Primary outcome: Bleeding on brushing, criteria:Asking patient, unit:Binary. Secondary outcome:Counting streptococcus mutans, criteria: Agar plate, unit: CFUs/mL
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pomegranate peel extract | Experimental | Pomegranate is antimicrobial, anti inflammatory and antioxidant |
|
| Chlorhexidine | Active Comparator | Chlorhexidine mouthwash is antiplaque treatment and effective against gingivitis |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Pomegranates peel extract | Drug | Pomegranate is antimicrobial |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Bleeding on brushing, Measurement: asking patient , Unit: Binary | 2 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Counting streptococcus mutans, Measurement: Agar plate, Unit: CFUs/mL | 2 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Heba M Fouad, Bachelor | Contact | 01001798183 | heba.fouad@dentistry.cu.edu.eg | |
| Manal El shiekh, Lecturer | Contact |
| Name | Affiliation | Role |
|---|---|---|
| Salah El Behery, Professor | Cairo University | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 23762148 | Background | Howell AB, D'Souza DH. The pomegranate: effects on bacteria and viruses that influence human health. Evid Based Complement Alternat Med. 2013;2013:606212. doi: 10.1155/2013/606212. Epub 2013 May 20. | |
| 26955605 | Background | Umar D, Dilshad B, Farhan M, Ali A, Baroudi K. The effect of pomegranate mouthrinse on Streptococcus mutans count and salivary pH: An in vivo study. J Adv Pharm Technol Res. 2016 Jan-Mar;7(1):13-6. doi: 10.4103/2231-4040.173266. |
| Label | URL |
|---|---|
| Related Info | View source |
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| ID | Term |
|---|---|
| D005884 | Gingival Hemorrhage |
| ID | Term |
|---|---|
| D006472 | Oral Hemorrhage |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
| D005882 | Gingival Diseases |
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| ID | Term |
|---|---|
| D002710 | Chlorhexidine |
| ID | Term |
|---|---|
| D001645 | Biguanides |
| D006146 | Guanidines |
| D000578 | Amidines |
| D009930 | Organic Chemicals |
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| Chlorhexidine |
| Drug |
Chlorhexidine mouthwash is antiplaque agent |
|
| 25728105 | Background | Tulsani SG, Chikkanarasaiah N, Siddaiah SB, Krishnamurthy NH. The effect of Propolis and Xylitol chewing gums on salivary Streptococcus mutans count: a clinical trial. Indian J Dent Res. 2014 Nov-Dec;25(6):737-41. doi: 10.4103/0970-9290.152182. |
| 12397186 | Background | Ajdic D, McShan WM, McLaughlin RE, Savic G, Chang J, Carson MB, Primeaux C, Tian R, Kenton S, Jia H, Lin S, Qian Y, Li S, Zhu H, Najar F, Lai H, White J, Roe BA, Ferretti JJ. Genome sequence of Streptococcus mutans UA159, a cariogenic dental pathogen. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14434-9. doi: 10.1073/pnas.172501299. Epub 2002 Oct 23. |
| 15943766 | Background | Filoche SK, Soma K, Sissons CH. Antimicrobial effects of essential oils in combination with chlorhexidine digluconate. Oral Microbiol Immunol. 2005 Aug;20(4):221-5. doi: 10.1111/j.1399-302X.2005.00216.x. |
| 24800189 | Background | Zarfeshany A, Asgary S, Javanmard SH. Potent health effects of pomegranate. Adv Biomed Res. 2014 Mar 25;3:100. doi: 10.4103/2277-9175.129371. eCollection 2014. |
| Related Info | View source |
| Related Info | View source |
| Related Info | View source |
| D010510 |
| Periodontal Diseases |
| D006470 | Hemorrhage |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |