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| Name | Class |
|---|---|
| A. Vogel | UNKNOWN |
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Pilot trial: 6-week single arm intervention. Healthy adults (male and female) consume Molkosan (fermented whey) twice a day (AM & PM).
Molkosan® is made from fresh organic whey using a special fermentation process involving lactic acid producing bacteria (L+ lactic acid 70g/L). The company, A.Vogel (Roggwil, Switzerland) will provide the product and we will collect biological samples for analysis in a proof of concept study design that will provide preliminary data for future larger studies.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Molkosan | Experimental | Consumption of Molkosan (fermented whey) 20ml to be diluted in 200ml water prior to use twice a day (morning & evening). Total duration was 6 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Molkosan | Dietary Supplement | Twice daily (AM and PM) 20ml of fermented whey concentrate consumed diluted in 200ml water |
|
| Measure | Description | Time Frame |
|---|---|---|
| Change in microbiota activity | Faecal short-chain fatty acids, measured by gas chromatography | Baseline, day 21 and 42 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in glucose tolerance (Oral glucose tolerance test (OGTT) | Six blood samples will be collected during the course of 3 hours (0, 30, 60, 90,120 and 180 min) using a cannulation after consuming 75 g of Polycal liquid (glucose load). Plasma glucose level and insulin are analysed as total area under the curve (AUC) and incremental AUC. | Baseline, day 21 and 42 |
| Measure | Description | Time Frame |
|---|---|---|
| Change in microbiota composition - 16s rRNA (ribosomal ribonucleic acid) sequencing | 16S rRNA extracted from fresh stool samples (<16hrs) | Baseline, day 21 and 42 |
| Subjective assessment of digestion and bowel movements |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Alexandra M Johnstone, Ph.D | Rowett Institute, University of Aberdeen | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The Rowett Institute, Human Nutrition Unit | Aberdeen | AB25 2ZD | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 33102510 | Derived | Smith NM, Maloney NG, Shaw S, Horgan GW, Fyfe C, Martin JC, Suter A, Scott KP, Johnstone AM. Daily Fermented Whey Consumption Alters the Fecal Short-Chain Fatty Acid Profile in Healthy Adults. Front Nutr. 2020 Sep 30;7:165. doi: 10.3389/fnut.2020.00165. eCollection 2020. |
| Label | URL |
|---|---|
| A. Vogel product website and description | View source |
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Unlabelled bottles of treatment
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Volunteer self-reported symptoms measured by questionnaire
| Baseline and day 14-18 |
| Energy intake | 4-day weighed food diary analysed for energy intake and macronutrient composition | Baseline and day 14-18 |
| Blood pressure | Repeated in triplicate, measured in mmHg | Screening, baseline and day 42 |
| Pulse | Triplicate measurement, expressed as beats per minute | Screening, baseline and day 42 |