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| Name | Class |
|---|---|
| Government Body Funding | UNKNOWN |
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The aim of this intervention study is to investigate the effect of a specific postbiotic (Lacticaseibacillus rhamnosus GG = LGG) and whey protein on immunity, recovery, and weight management in young adults. The objective is based on previous knowledge about the health-promoting effects of these factors. A new goal is to study the combined effect of the postbiotic and whey protein. The results of the study can be utilized to promote the health of the young adults.
The study is a randomized, double-blind, 3-arm intervention involving young adults (n=160). Participants are randomized into three groups to receive different study product, and differences among the groups will be compared, for example, in terms of gut microbiota, weight changes, and inflammatory markers derived from blood samples.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Placebo milk product | Placebo Comparator | Use of low protein milk product |
|
| Whey protein hydrolysate milk product | Active Comparator | Use of milk product with whey protein hydrolysate |
|
| Postbiotic and whey protein hydrolysate milk product | Active Comparator | Use of milk product with whey protein hydrolysate and Lacticaseibacillus rhamnosus GG |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Placebo Comparator | Dietary Supplement | Low-protein milk product |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Concentrations of inflammatory markers from the blood samples | hs-CRP (High-Sensitivity C-Reactive Protein), haptoglobin, suPAR (soluble urokinase-type Plasminogen Activator Receptor) | At the baseline (week 0) and after eight weeks (last visit) |
| Measure | Description | Time Frame |
|---|---|---|
| Changes in the gut microbiota composition, diversity and function | Gut microbiota composition and function in feces by metagenomics shotgun sequencing | At the baseline (week 0) and after eight weeks (last visit) |
| Weight of the participant |
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Inclusion Criteria:
- healthy
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Kirsi Laitinen, Professor | University of Turku | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Turku | Turku | Finland |
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| Whey protein hydrolysate milk product |
| Dietary Supplement |
Milk product with whey protein hydrolysate |
|
| Postbiotic and whey protein hydrolysate milk product | Dietary Supplement | Milk product with whey protein hydrolysate and Lacticaseibacillus rhamnosus GG |
|
Weight
| At the baseline (week 0), at four weeks and after eight weeks (last visit) |
| Waist circumference of the participant | Waist circumference | At the baseline (week 0) and after eight weeks (last visit) |
| Infections during the intervention | Self-reported infections during the intervention | During intervention (Eight weeks) |
| Development of physical fitness | Based on walking test | At the baseline (week 0) and after eight weeks (last visit) |
| Changes in the sleep quality | Monitoring sleep quality using a sports watch. | During intervention (Eight weeks) |
| Changes in recovery | Monitoring recovery using a sports watch. | During intervention (Eight weeks) |
| Blood pressure | Blood pressure | At the baseline (week 0), at four weeks and after eight weeks (last visit) |
| BMI | Body Mass Index (BMI) | At the baseline (week 0), at four weeks and after eight weeks (last visit) |