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| Name | Class |
|---|---|
| Ege University | OTHER |
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The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preterm labor.
The secondary objective of the study is to analyze the relationship between preterm labor and periodontal infection, using clinical, biochemical and microbiological methods.
Preterm infants are born prior to completion of 37 weeks of gestation. Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preterm labor. It is believed that the results will set light to the etiology of preterm labor and will help to develop strategies to prevent the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| preterm labor | Workgroup consists of patients which diagnosed with preterm labor between the age of 21 and 34 |
| |
| healthy | 24-36 6/7 weeks of pregnant between the age of 21 and 34 |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| preterm labor | Diagnostic Test | liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine |
|
| Measure | Description | Time Frame |
|---|---|---|
| prostaglandin E2 | prostaglandin E2 levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml | 1 Day |
| TNF-Alpha | TNF-Alpha levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml | 1 day |
| IL-1beta | IL-1beta levels will be evaluated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Porphyromonas gingivalis | Presence of Porphyromonas gingivalis will be checked by rPCR method. Score 1: Present Score 2: None | 1 Day |
| Tannerella Forsythia | Presence of Tannerella Forsythia will be checked by rPCR method. Score:1 Present. Score 2: None |
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Inclusion Criteria:
Exclusion Criteria:
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pregnant women
The study is planned to be a case-control study. Workgroup consists of 50 patients which diagnosed with preterm labor between the age of 21 and 34. Control group consists of healthy females 24-36 6/7 weeks of pregnant with no history of preterm labor.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gül Yıldız Telatar, Dr. | Contact | 05365404555 | gulyildiz@gmail.com | |
| Beril Gürlek, Dr. | Contact | 05535979403 | berilsem@yahoo.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ege University Dentistry Faculty | Recruiting | Izmir | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28282773 | Background | Puertas A, Magan-Fernandez A, Blanc V, Revelles L, O'Valle F, Pozo E, Leon R, Mesa F. Association of periodontitis with preterm birth and low birth weight: a comprehensive review. J Matern Fetal Neonatal Med. 2018 Mar;31(5):597-602. doi: 10.1080/14767058.2017.1293023. Epub 2017 Feb 28. |
| Label | URL |
|---|---|
| Association of periodontitis with preterm birth and low birth weight | View source |
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Data will be available within 6 months of study completion
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Tissue samples from four centers will be taken from the maternal and fetal surfaces of the placenta Saliva samples of pregnant women
|
| healthy | Diagnostic Test | liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine |
|
|
| 1 Day |
| İzmir Health Sciences University, Tepecik Training and Research Hospital Department of Obstetrics and Gynecology | Recruiting | Izmir | Turkey (Türkiye) |
|
| Recep Tayyip Erdogan University Dentistry Faculty | Active, not recruiting | Rize | 53000 | Turkey (Türkiye) |
| Recep Tayyip Erdogan University Faculty of Medicine | Active, not recruiting | Rize | 53000 | Turkey (Türkiye) |
| Recep Tayyip Erdogan University | Active, not recruiting | Rize | 53000 | Turkey (Türkiye) |
| Glaskow Dental School , School of Medicine University of Glasgow | Active, not recruiting | Glaskow | United Kingdom |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D016482 | Urinalysis |
| D000072001 | Diet, Healthy |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D019963 | Clinical Chemistry Tests |
| D003950 | Diagnostic Techniques, Urological |
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
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