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| Name | Class |
|---|---|
| Ege University | OTHER |
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The primary objective of the study is to assess the incidence and severity of the periodontal infection of patients with preeclampsia.
The secondary objective of the study is to analyze the relationship between preeclampsia and periodontal infection, using clinical, biochemical and microbiological methods.
Preeclampsia is identified as an important cause for mother and newborn mortality. Inspite of extensive research, the exact etiological relations have not been established.
Periodontal disease is a subclinical and persistent infection source which induces the systemic inflammatory reactions and increases the risk of preeclampsia. It is believed that the results will set light to the etiology of preeclampsia and will help to develop strategies to prevent the disease.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| preeclampsia | 18-40 aged diagnosed with preeclampsia |
| |
| control | 18- 40 aged healthy females over 37. weeks of pregnant with no history of preeclampsia |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| preeclampsia | Diagnostic Test | liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine |
|
| Measure | Description | Time Frame |
|---|---|---|
| prostaglandin E2 | prostaglandin E2 levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:29-97 pg / ml | 1 Day |
| TNF-Alpha (Tumor necrosis factor -Alpha) | TNF-Alpha levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:42-203pg/ml | 1 day |
| IL-1beta (Interleukin 1 beta) | IL-1beta levels will be evaulated in salivary, serum and placenta samples using ELISA test Normal value:3-227pg/ml | 1 day |
| Measure | Description | Time Frame |
|---|---|---|
| Porphyromonas gingivalis | Presence of Porphyromonas gingivalis will be checked by rPCR method. Score 1: Present Score 2: None Tannerella Forsythia (+,-) | 1 Day |
| Tannerella Forsythia | Presence of Tannerella Forsythia will be checked by rPCR method. Score:1 Present. Score 2: None |
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Inclusion Criteria:
Exclusion Criteria:
pregnant women
The study is planned to be a case-control study. Workgroup consists of 50 patients which diagnosed with preeclampsia between the age of 18 and 40. Control group consists of healthy females over 37. weeks of pregnant with no history of preeclampsia.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Gül Yıldız Telatar, Dr. | Contact | 05365404555 | gulyildiz@gmail.com | |
| Beril Gürlek, Dr. | Contact | 05535979403 | berilsem@yahoo.com |
| Name | Affiliation | Role |
|---|---|---|
| Gül Yıldız Telatar | Recep Tayyip Erdogan University Dentistry Faculty | Principal Investigator |
| Önder Gürlek, Dr. | Ege University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ege University Dentistry Faculty | Recruiting | Izmir | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 29568173 | Background | Jaiman G, Nayak PA, Sharma S, Nagpal K. Maternal periodontal disease and preeclampsia in Jaipur population. J Indian Soc Periodontol. 2018 Jan-Feb;22(1):50-54. doi: 10.4103/jisp.jisp_363_15. |
| Label | URL |
|---|---|
| Maternal periodontal disease and preeclampsia in Jaipur population. | View source |
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Data will be available within 6 months of study completion
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Tissue samples from four centers will be taken from the maternal and fetal surfaces of the placenta Saliva samples of pregnant women
|
| control | Diagnostic Test | liver function tests, kidney function tests and platelets measures the ratio of protein to creatinine |
|
|
| 1 Day |
| İzmir Health Sciences University, Tepecik Training and Research Hospital Department of Obstetrics and Gynecology | Recruiting | Izmir | Turkey (Türkiye) |
|
| Recep Tayyip Erdogan University Dentistry Faculty | Active, not recruiting | Rize | 53000 | Turkey (Türkiye) |
| Recep Tayyip Erdogan University Faculty of Medicine | Active, not recruiting | Rize | 53000 | Turkey (Türkiye) |
| Glaskow Dental School , School of Medicine University of Glasgow | Active, not recruiting | Glaskow | United Kingdom |
| ID | Term |
|---|---|
| D011225 | Pre-Eclampsia |
| D010510 | Periodontal Diseases |
| ID | Term |
|---|---|
| D046110 | Hypertension, Pregnancy-Induced |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D016482 | Urinalysis |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
| D019963 | Clinical Chemistry Tests |
| D003950 | Diagnostic Techniques, Urological |
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