Randomized controlled prospective comparative study

This study is intended to be a randomized controlled comparative study conducted to compare the effect of monthly versus two doses of ante-natal intermittent preventive treatment with sulphadoxine-pyrimethamine

Inclusion Criteria:

• Pregnant women
• Gestational age between 16 and 28weeks.
• No history of use of sulphadoxine-pyrimethamine prior to recruitment
• Not on any medication for prophylaxis

Exclusion Criteria:

• Anaemia
• HIV positive women
• Pre-existing medical conditions e.g diabetes mellitus, haemoglobinopathy, hypertension, kidney disease, heart disease, any endocrine disorder like hypo/hyperthyroidism, Cushing' disease, connective tissue disorders like systemic lupus erythematosus, antiphospholipid syndrome or any otherautoimmune disease with poor feto-maternal outcomes in pregnancy.
• History of Glucose -6-Phosphate Dehydrogenase (G6PD) deficiency in patient
• Allergy to sulphonamides or pyrimethamine.
• Non consenting patients
• Multiple gestations

Sexes eligible for the study