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| Name | Class |
|---|---|
| University of Ibadan | OTHER |
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Randomized controlled single blind prospective comparative study.
This study is intended to be a randomized controlled single blind prospective comparative study conducted to compare the efficacy of three, monthly doses of sulphadoxine-pyrimethamine as intermittent preventive therapy with Mefloquine as-intermittent preventive therapy in HIV-infected pregnant women.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mefloquine | Active Comparator | Tabs Mefloquine 250mg 3 doses 4 weeks apart |
|
| Sulphadoxine-Pyrimethamine | Active Comparator | 500mg of Sulphadoxine and 25mg of Pyrimethamine 3tablets 4 weeks apart for 3 doses |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mefloquine | Drug | Tabs Mefloquine 250mg |
|
|
| Measure | Description | Time Frame |
|---|---|---|
| Level of malaria parasitemia in HIV positive women at delivery after administration of Mefloquine or sulphadoxine-pyrimethamine as prophylaxis for malaria in pregnancy | 6 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| AYODELE O AROWOJOLU, MBBS IBADAN | UNIVERSITY COLLEGE HOSPITAL,IBADAN,OYO STATE, NIGERIA | Study Director |
| ORIYOMI O AKINYOTU, MBBS IBADAN | UNIVERSITY COLLEGE HOSPITAL,IBADAN,OYO STATE,NIGERIA | Principal Investigator |
| ADENIKE F BELLO, MBBS IBADAN | UNIVERSITY COLLEGE HOSPITAL,IBADAN,OYO STATE, NIGERIA | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University College Hospital | Ibadan | Oyo State | 200001 | Nigeria |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 8702037 | Background | Steketee RW, Wirima JJ, Slutsker L, Khoromana CO, Heymann DL, Breman JG. Malaria treatment and prevention in pregnancy: indications for use and adverse events associated with use of chloroquine or mefloquine. Am J Trop Med Hyg. 1996;55(1 Suppl):50-6. doi: 10.4269/ajtmh.1996.55.50. | |
| 39324693 | Derived | Pons-Duran C, Wassenaar MJ, Yovo KE, Marin-Carballo C, Briand V, Gonzalez R. Intermittent preventive treatment regimens for malaria in HIV-positive pregnant women. Cochrane Database Syst Rev. 2024 Sep 26;9(9):CD006689. doi: 10.1002/14651858.CD006689.pub3. |
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| ID | Term |
|---|---|
| D008288 | Malaria |
| D006679 | HIV Seropositivity |
| ID | Term |
|---|---|
| D011528 | Protozoan Infections |
| D010272 | Parasitic Diseases |
| D007239 | Infections |
| D000096724 | Mosquito-Borne Diseases |
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| ID | Term |
|---|---|
| D015767 | Mefloquine |
| C001205 | fanasil, pyrimethamine drug combination |
| ID | Term |
|---|---|
| D011804 | Quinolines |
| D006574 | Heterocyclic Compounds, 2-Ring |
| D000072471 | Heterocyclic Compounds, Fused-Ring |
| D006571 | Heterocyclic Compounds |
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| Sulphadoxine-Pyrimethamine | Drug | Sulphadoxine 500mg , Pyrimethamine 25mg |
|
|
| 29719927 | Derived | Akinyotu O, Bello F, Abdus-Salam R, Arowojolu A. Comparative study of mefloquine and sulphadoxine-pyrimethamine for malaria prevention among pregnant women with HIV in southwest Nigeria. Int J Gynaecol Obstet. 2018 Aug;142(2):194-200. doi: 10.1002/ijgo.12516. Epub 2018 May 25. |
| D000079426 |
| Vector Borne Diseases |
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |