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Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%. That so-called "buffer response" assumes that when portal flow increases, hepatic artery flow decreases. During fluid challenge in intensive care unit, fluid challenge is often administered to improve hepatic perfusion. That observation is not demonstrated. The aim of the study is to test buffer response and portal flow during fluid challenge.
Prospective monocentric study at Amiens Hospital University. 20 volunteers subjects will be include after providing informed consent. Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MRI (magnetic resonance imaging) | Other | Hepatic blood flow baseline will be measured using MRI. Fluid challenge of 500 ml of NaCl 0.9% will be administered during 10 minutes. Before and After fluid challenge, MRI will be performed to compare flow changes. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| MRI (magnetic resonance imaging) | Device | Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Portal blood flow measure before and after fluid challenge | Fluid challenge will be performed with 500 ml of intra venous NaCl (0.9%). Hepatic blood flow measurement will be performed using MRI (magnetic resonance imaging). | Two hours: the difference in hepatic portal flow before and after a volume expansion of 500 ml NaCl 0.9%. |
| Measure | Description | Time Frame |
|---|---|---|
| Hepatic artery blood flow measure before and after fluid challenge | Hepatic artery blood flow measure before and after a volume expansion of 500 ml NaCl 0.9%. | Two hours |
| Measure | Description | Time Frame |
|---|---|---|
| Flow ratio of portal flow on hepatic artery flow | Flow ratio of portal flow on hepatic artery flow before and after a volume expansion of 500 ml NaCl 0.9%. | Two hours |
Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Amiens-Picardie | Amiens | 80000 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35574483 | Result | Abou-Arab O, Beyls C, Moussa MD, Huette P, Beaudelot E, Guilbart M, De Broca B, Yzet T, Dupont H, Bouzerar R, Mahjoub Y. Portal Vein Pulsatility Index as a Potential Risk of Venous Congestion Assessed by Magnetic Resonance Imaging: A Prospective Study on Healthy Volunteers. Front Physiol. 2022 Apr 29;13:811286. doi: 10.3389/fphys.2022.811286. eCollection 2022. |
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| ID | Term |
|---|---|
| D008279 | Magnetic Resonance Imaging |
| ID | Term |
|---|---|
| D014054 | Tomography |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
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