Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

Optimization of PK/PD Target Attainment for Meropenem in Critically Ill Patients With Sepsis

WP1.1. PK/PD target attainment: Plasma exposure, Excretion via urine & ELF exposure; WP1.2. Predictive dosing algorithm; WP1.3. ECMO subset

First, the investigators will document exposure to meropenem in plasma and epithelial lining fluid. Moreover excretion in urine will be documented.

Second, the investigators will try to identify risk factors for not attaining PK/PD target. Based on significant predictors for target non attainment a predictive dosing algorithm will be constructed.

Finally in a small subset of ECMO patients PK exposure will be explored.

Inclusion Criteria:

• Severe sepsis or septic shock
• Admitted to an ICU ward
• Treated with meropenem

Exclusion Criteria:

• eGFR(CKD-EPI) < 70ml/min/1.73m²
• Renal replacement therapy
• Pregnancy
• DNR code 1-3