Pharmacokinetic/Pharmacodynamic Evaluation Amikacin in Critically Ill Patients Admitted at the Emergency Department

Pharmacokinetic/Pharmacodynamic (PK/PD) Evaluation of Amikacin in Patients With Severe Sepsis or Septic Shock Admitted at the Emergency Department(ED)

The aim of the study is the evaluation of PK/PD target attainment of amikacin in ED patients with severe sepsis and septic shock.

Inclusion Criteria:

- patients admitted at the emergency department with a diagnosis of severe sepsis or septic shock in whom amikacin is indicatied

Exclusion Criteria:

• < 18 years
• pregnancy
• burns
• amikacin treatment in the previous 2 weeks
• known allergy to aminoglycosides
• Do Not Reanimate Code ≥ 2
• Hospitalized patients with a prolonged deep venous or arterial catheder
• Continuous renal replacement, intermittent hemodialysis and death within the time of start of amikacin replacement and 1 hour later